Evidence map›Paper›PMID 40597144›Full record

ArticleJournal of translational medicine2025

Can mutation abundance assess the biological behavior of BRAF

Yeqin Ni, Ping Song, Xiangfeng Lin, Jingjing Shi, Qian Shi, Yuanhui Li, Siyu Zhu, Tianhan Zhou, Yanping Xun, Shirong Zhang and 22 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Yeqin Ni *Department of Surgical Oncology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, No. 261, Huansha Road, Shangcheng district, Hangzhou, Zhejiang, 310006, China.
Ping Song *Department of Surgical Oncology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, No. 261, Huansha Road, Shangcheng district, Hangzhou, Zhejiang, 310006, China.
Xiangfeng Lin *Department of Thyroid Surgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, No. 20, Yuhuangding East Road, Zhifu District, Yantai, Shandong, 264000, China.
Jingjing Shi *Department of Surgical Oncology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, No. 261, Huansha Road, Shangcheng district, Hangzhou, Zhejiang, 310006, China.
Qian Shi *Department of Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Dongjiaomin lane No. 1, Dongcheng District, Beijing, 100101, China.
Yuanhui LiDepartment of Surgical Oncology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, No. 261, Huansha Road, Shangcheng district, Hangzhou, Zhejiang, 310006, China.
Siyu ZhuDepartment of Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Dongjiaomin lane No. 1, Dongcheng District, Beijing, 100101, China.
Tianhan ZhouDepartment of General Surgery, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310006, China.
Yanping XunCentre of Translational Medicine, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, Zhejiang, 310006, China.
Shirong ZhangCentre of Translational Medicine, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, Zhejiang, 310006, China.
Xingchang RenDepartment of Pathology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310006, China.
Kaining LuDepartment of Breast Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 211166, China.
Fan WuDepartment of Surgical Oncology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, No. 261, Huansha Road, Shangcheng district, Hangzhou, Zhejiang, 310006, China.
Wei WangDepartment of Pathology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, Zhejiang, 310006, China.
Pan ZhaoDepartment of Pathology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, Zhejiang, 310006, China.
Rongjing ZhouDepartment of Pathology, Affiliated Hangzhou Cancer Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China.
Wenhua ZhangDepartment of Pathology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, Zhejiang, 310006, China.
Dandan LiDepartment of Pathology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, Zhejiang, 310006, China.
Jiaoping ZhangDepartment of Surgical Oncology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, No. 261, Huansha Road, Shangcheng district, Hangzhou, Zhejiang, 310006, China.
Chuanghua ChenDepartment of Ultrasonography, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, Zhejiang, 310006, China.
Linlin MaoDepartment of Surgical Oncology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, No. 261, Huansha Road, Shangcheng district, Hangzhou, Zhejiang, 310006, China.
Li ZhouDepartment of Surgical Oncology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, No. 261, Huansha Road, Shangcheng district, Hangzhou, Zhejiang, 310006, China.
Gang PanDepartment of Surgical Oncology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, No. 261, Huansha Road, Shangcheng district, Hangzhou, Zhejiang, 310006, China.
You PengDepartment of Surgical Oncology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, No. 261, Huansha Road, Shangcheng district, Hangzhou, Zhejiang, 310006, China.
Yunxian YuDepartment of Epidemiology & biostatistics, School of Public Health, Zhejiang University, Hangzhou, Zhejiang, 310006, China.
Yuying ChenThe Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310006, China.
Rong NiThe Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310006, China.
Guhan LuoThe Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310006, China.
Yu ZhangDepartment of Surgical Oncology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, No. 261, Huansha Road, Shangcheng district, Hangzhou, Zhejiang, 310006, China. zhangyu89@zju.edu.cn.
Jugao FangDepartment of Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Dongjiaomin lane No. 1, Dongcheng District, Beijing, 100101, China. fangjugao2@ccmu.edu.cn.
Haitao ZhengDepartment of Thyroid Surgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, No. 20, Yuhuangding East Road, Zhifu District, Yantai, Shandong, 264000, China. 160907122@stu.cuz.edu.cn.
Dingcun LuoDepartment of Surgical Oncology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, No. 261, Huansha Road, Shangcheng district, Hangzhou, Zhejiang, 310006, China. ldc65@zju.edu.cn.ORCID 0000-0002-7320-4202

Funding

Medical and Health Technology Projects of Hangzhou Z20210025Medical Science and Technology Project of Zhejiang Province 2022KY939Zhejiang Provincial Basic Public Welfare Research Project LGF22H160082
6 · The paper itself

Abstract

backgroundBRAF

methodsPostoperative formalin-fixed paraffin-embedded (FFPE) specimens from 528 PTC patients formed the retrospective cohort, and preoperative fine-needle aspiration (FNA) specimens from 167 PTC patients formed the prospective cohort. Furthermore, 74 FNA specimens were collected from two additional hospitals to form the external cohort. Droplet digital polymerase chain reaction (ddPCR) was used to detect BRAF

resultsUnivariate and multivariate analysis of the retrospective, prospective and external cohorts indicated that BRAF

conclusionsBRAF

trial registrationChiCTR, ChiCTR2300071472. Registered 31 July 2016 - Retrospectively registered, https://www.chictr.org.cn/showproj.html?proj=190478 .

Indexed as

Amino Acid SubstitutionMutationProto-Oncogene Proteins B-rafThyroid Cancer, PapillaryThyroid NeoplasmsAdultAgedBiopsy, Fine-NeedleFemaleHumansMaleMiddle AgedRetrospective StudiesROC CurveBRAF protein, humanProto-Oncogene Proteins B-rafBRAF V600E mutation abundanceClinical decisionMachine learningRisk stratificationThyroid cancer

Identifiers

PMID40597144
PMCPMC12211382

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.