ArticleBMC biology2025
doc2a and doc2b contribute to locomotor and social behaviors by down-regulating npas4b in zebrafish.
Article in BMC biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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9 authors.
Funding
Abstract
backgroundCopy number variations (CNVs) occurring on chromosome 16p11.2 are associated with various neurodevelopmental disorders, including autism spectrum disorder (ASD), schizophrenia, and intellectual disability. Among the genes situated within the critical CNV region, DOC2A is noteworthy. We generated frameshift mutations in doc2a (double C2-like domain-containing protein a) and its paralog doc2b (double C2-like domain-containing protein b) in zebrafish via CRISPR-Cas9 respectively and obtained double-mutant doc2a
resultsdoc2a
conclusionsThis study suggests that DOC2A in the critical region of 16p11.2 may contribute to the pathogenesis of autism by interacting with other genes, such as DOC2B, and that the downregulation of NPAS4 may play an important role in autism.
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