Evidence map›Paper›PMID 40597058›Full record

ArticleBMC psychiatry2025

Cognitive behavioural therapy in comparison to treatment as usual in young adults at high risk of developing bipolar disorder (Bipolar At Risk): a randomised controlled trial to investigate the efficacy of a treatment approach targeted at key appraisal change: Bipolar At Risk Trial II (BART II).

Sophie Parker, Lydia Pearson, Rebekah Carney, Richard P Bentall, Matthew R Broome, Emma Cernis, Timothy Clarke, Steven Jones, Katherine Moran, Jonathan Wilson and 11 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Sophie ParkerYouth Mental Health Research Unit, Greater Manchester Mental Health NHS Foundation Trust, Manchester, M25 3BL, UK. sophie.parker@gmmh.nhs.uk.
Lydia PearsonYouth Mental Health Research Unit, Greater Manchester Mental Health NHS Foundation Trust, Manchester, M25 3BL, UK.
Rebekah CarneyYouth Mental Health Research Unit, Greater Manchester Mental Health NHS Foundation Trust, Manchester, M25 3BL, UK.
Richard P BentallSchool of Psychology, Faculty of Science, University of Sheffield, Sheffield, UK.
Matthew R BroomeInstitute for Mental Health, School of Psychology, University of Birmingham, Birmingham, UK.
Emma CernisInstitute for Mental Health, School of Psychology, University of Birmingham, Birmingham, UK.
Timothy ClarkeChildren and Young People's Mental Health Service, Norfolk and Suffolk NHS Foundation Trust, Norwich, UK.
Steven JonesSpectrum Centre for Mental Health, Lancaster University, Lancaster, UK.
Katherine MoranChildren and Young People's Mental Health Service, Norfolk and Suffolk NHS Foundation Trust, Norwich, UK.
Jonathan WilsonChildren and Young People's Mental Health Service, Norfolk and Suffolk NHS Foundation Trust, Norwich, UK.
Isabel ColemanYork Trials Unit, University of York, York, UK.
Catherine HewittYork Trials Unit, University of York, York, UK.
Wendy JonesYouth Mental Health Research Unit, Greater Manchester Mental Health NHS Foundation Trust, Manchester, M25 3BL, UK.
Heather LawYouth Mental Health Research Unit, Greater Manchester Mental Health NHS Foundation Trust, Manchester, M25 3BL, UK.
Sarah PetersDivision of Psychology and Mental Health, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, M13 9PL, UK.
Gemma ShieldsDivision of Psychology and Mental Health, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, M13 9PL, UK.
David ShiersDivision of Psychology and Mental Health, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, M13 9PL, UK.
Luke StrachanYork Trials Unit, University of York, York, UK.
Anton StrongYouth Mental Health Research Unit, Greater Manchester Mental Health NHS Foundation Trust, Manchester, M25 3BL, UK.
Judith WatsonYork Trials Unit, University of York, York, UK.
Chris J SuttonLancashire Clinical Trials Unit, University of Central Lancashire, Preston, UK.

Funding

Efficacy and Mechanism Evaluation (EME) Programme, an MRC and NIHR partnership NIHR132622
6 · The paper itself

Abstract

backgroundResearch has demonstrated the ability to identify and treat individuals at high risk of developing psychosis. It is possible to use a similar strategy to identify people who have an emergent risk of bipolar disorder (BD). Interventions during the early phase may improve outcomes and reduce risk of transition. Criteria have been established to identify individuals considered to be at high risk for developing BD, also known as Bipolar At Risk (BAR). Offering a psychological intervention may provide the possibility of prevention. Evaluating efficacy and the mechanisms by which this treatment works is now required.

methodsA multicentre, rater-masked randomised controlled trial with two parallel arms will compare cognitive behaviour therapy (CBT) for young people meeting BAR criteria (CBT DISCUSSION: Our efficacy hypotheses are CBT TRIAL REGISTRATION/STATUS: The trial protocol is registered with ISRCTN (ISRCTN13363197, registered on 25th January 2023). Recruitment started in February 2023 and is ongoing.

Indexed as

Bipolar DisorderCognitive Behavioral TherapyAdolescentAdultFemaleHumansMaleMulticenter Studies as TopicRandomized Controlled Trials as TopicTreatment OutcomeYoung AdultBipolar at riskBipolar disorderCognitive behavioural therapyEarly detectionEarly interventionMood swingsPreventionPsychological therapyRandomised controlled trialYouth mental health

Identifiers

PMID40597058
PMCPMC12219869

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.