Evidence map›Paper›PMID 40596976›Full record

ArticleBMC nephrology2025

Combined predictive value of prognostic nutritional index and neutrophil to lymphocyte ratio for all-cause mortality risk in maintenance hemodialysis patients: a cohort study followed for 5 years.

Fang Xu, Shuang Cheng, Peng Shu, Yilan Liang, Xia Wang, Haitao Bai

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Article in BMC nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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4citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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4 citing papers in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Fang Xu *Department of Nephrology, Tongji Medical College, The Central Hospital of Wuhan, Huazhong University of Science and Technology, Wuhan, 430014, China.
Shuang Cheng *Department of Nephrology, Tongji Medical College, The Central Hospital of Wuhan, Huazhong University of Science and Technology, Wuhan, 430014, China.
Peng ShuDepartment of Nephrology, Tongji Medical College, The Central Hospital of Wuhan, Huazhong University of Science and Technology, Wuhan, 430014, China.
Yilan LiangDepartment of Nephrology, Tongji Medical College, The Central Hospital of Wuhan, Huazhong University of Science and Technology, Wuhan, 430014, China.
Xia WangDepartment of Nephrology, Tongji Medical College, The Central Hospital of Wuhan, Huazhong University of Science and Technology, Wuhan, 430014, China.
Haitao BaiDepartment of Nephrology, Tongji Medical College, The Central Hospital of Wuhan, Huazhong University of Science and Technology, Wuhan, 430014, China. 13007152231@163.com.

Funding

Chen Xiaoping Foundation for the Development of Science and Technology of Hubei Province CXPJJH124001-2404
6 · The paper itself

Abstract

backgroundTo assess the prognostic value of the prognostic nutritional index (PNI) alongside the neutrophil-to-lymphocyte ratio (NLR) in forecasting all-cause mortality in patients undergoing maintenance hemodialysis (MHD), and to pinpoint independent risk factors linked to all-cause mortality, thereby facilitating the guidance of prompt clinical interventions.

methodsA retrospective cohort investigation was carried out with the gathering of comprehensive demographic and clinical biochemical information. The follow-up period ended in December 2024, with all-cause mortality serving as the primary outcome measure. The predictive capabilities of PNI and NLR regarding all-cause mortality in MHD patients were evaluated through receiver operating characteristic (ROC) curve analysis. In addition to the plotting of Kaplan-Meier curves, the Cox model was utilized to pinpoint risk factors affecting 5-year all-cause mortality in MHD patients.

resultsA sum of 632 patients receiving MHD was analyzed during the follow-up. The area under the curve (AUC) for PNI and NLR was 0.739 and 0.668, with an optimal cutoff value of 43.094 and 2.937, respectively. Furthermore, patients presenting a PNI of ≥ 43.094 showed a better cumulative survival rate throughout the follow-up when compared to those with a PNI of < 43.094 (χ² = 56.461, P < 0.001). In contrast, patients with an NLR of ≥ 2.937 exhibited a diminished cumulative survival rate as opposed to those with an NLR under 2.937 (χ² = 125.414, P < 0.001). The Cox regression model identified male sex, utilization of central venous catheters (CVCs), an NLR of ≥ 2.937, increased absolute neutrophil count, and elevated aspartate aminotransferase (AST) levels for predicting 5-year all-cause mortality independently (P < 0.05). Conversely, a PNI of ≥ 43.094, along with high levels of hemoglobin, urea, and uric acid, were recognized as protective factors (P < 0.05).

conclusionBoth PNI and NLR have significant predictive value concerning all-cause mortality in MHD patients. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

Kidney Failure, ChronicLymphocytesNeutrophilsNutrition AssessmentRenal DialysisAgedCohort StudiesFemaleFollow-Up StudiesHumansLymphocyte CountMaleMiddle AgedPredictive Value of TestsPrognosisRetrospective StudiesAll-cause mortalityCohort studyMaintenance hemodialysisNeutrophil to lymphocyte ratioPredictive factorsPrognostic nutritional index

Identifiers

PMID40596976
PMCPMC12220028

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