ArticleBMC cancer2025
Urinary paranitrophenol levels and risk of cancer mortality: evidence from NHANES.
Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParanitrophenol, a metabolite of organophosphate insecticides, was associated with various adverse health outcomes. However, the association of Paranitrophenol with all-cause and cancer mortality in adults remains unclear.
methodsA total of 3,362 participants (1680 male) were included from the National Health and Nutrition Examination Surveys (NHANES). Urinary Paranitrophenol was measured using ultra-high-performance LC-MS/MS. Mortality status and causes were obtained from National Death Index. Cox proportional hazards regression analysis was performed to explore the associations between Paranitrophenol and all-cause and cancer mortality, respectively.
resultsAfter a follow-up of 22.75 thousand person-years, there were 297 deaths from all causes and 69 deaths from cancer. Comparing with the lowest quartile, the highest quartile was not associated with all-cause mortality in the neither univariate model nor adjusted model. In terms of cancer mortality, the hazard ratios and 95% confidence interval of the highest quartile is 0.44 (0.21-0.93) in the univariate model, 0.40 (0.18-0.86) in the partly-adjusted model, and 0.40 (0.18-0.88) in the fully-adjusted model.
conclusionHigher urinary Paranitrophenol levels were associated with a decreased risk of cancer mortality. This association remained independent of demographics, lifestyle factors, and comorbidities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.