ArticleBMC pediatrics2025
Growth trajectories of children and adolescents with osteogenesis imperfecta in a reference center in Rio de janeiro, Brazil.
Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Osteogenesis imperfecta: a registry-based study of the clinical symptoms of disease in a large cohort of Italian patients.Frontiers in endocrinology · 2026Article
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5 authors.
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Abstract
backgroundOsteogenesis Imperfecta (OI) is a rare genetic disorder affecting collagen production, crucial for bone and connective tissue. Monitoring growth in children with OI is essential for detecting comorbidities. Despite common stature deficits, specific growth charts are crucial for sensitively tracking changes and identifying additional issues in this population. The aim of this study is to evaluate weight, height and BMI trajectories in Brazilian patients with Osteogenesis Imperfecta (OI), proposing specific growth charts.
methodsWeight and height repeated measures from birth to 19 years old were collected from medical records of all patients with OI treated in a reference center in Rio de Janeiro, Brazil. The GAMLSS statistical package (R software) was used to generate charts of weight-for-age, height-for-age and BMI-for-age, stratified for gender and OI subtype. Charts were compared to the World Health Organization (WHO) standards. The association with other variables was investigated using linear mixed effects regression.
results237 participants were included (type I = 134; type III = 41, type IV = 57; type V = 5). Factors associated with growth were: gender, OI subtype, pamidronate use, and rod placement. In type I, weight and height trajectories followed the pattern of WHO standards, but with a deficit in both genders. The growth of types III and IV was significantly lower compared to type I only after 2 years old for weight and all over the period for height. In general, there is greater impairment of height than weight, so the BMI chart is closer to the WHO standard, sometimes even surpassing it, especially in more severe phenotypes.
conclusionChildren and adolescents with OI have compromised anthropometric measures and their nutritional evaluation must be done by specific growth charts. This work is an important step towards facilitating the clinical evaluation of these patients and can be used as reference for Brazilian population.
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