Observational studyBMC ophthalmology2025
Evaluation of refractive, tomographic and biomechanical changes after customized accelerated corneal collagen cross-linking in keratoconus patients: a retrospective observational study.
Observational study in BMC ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Timing of corneal cross-linking in eyes undergoing intracorneal ring segments for keratoconus: same-day versus staged CXL: a systematic review and meta-analysis.International ophthalmology · 2026Pooled it
- Beyond the Cornea: Early Changes in Scleral, Iris, and Corneal Parameters After Corneal Collagen Cross-Linking.Journal of clinical medicine · 2026Article
- Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the refractive, keratometric, and biomechanical changes in keratoconus patients following modified accelerated corneal cross-linking (A-CXL).
methodsThis retrospective observational study analyzed clinical data from patients with progressive keratoconus who underwent modified A-CXL with a prolonged riboflavin imbibition period prior to UV irradiation. Preoperative and post-operative data on vision, refraction, tomography using OCULUS Pentacam and biomechanics using Corvis ST were analyzed at various follow-up intervals. Subgroup analysis was conducted based on topographic keratoconus classification. Statistical comparison was performed to assess changes in these parameters over time.
resultsA total of 70 eyes of 55 patients were included. A statistically significant improvement in mean change of logMAR BCVA was noted at 6 and 12 months (p = 0.006 and p = 0.018). Six months following A-CXL, statistically significant improvements were observed in keratometry and pachymetry (p = 0.003 and p < 0.001). Mean changes in biomechanical parameters deformation amplitude ratio (DAR) and Integrated Radius (IR) were found to be significantly decreased at 6 months (p = 0.001 and p = 0.011). Other biomechanical parameters SPA1, SSI and ARTh had no significant changes suggesting stability. Comparative analysis between different stages of keratoconus revealed that patients classified under TKC-4 exhibited greater improvement in keratometry compared to those with TKC-2 and TKC-3 staging.
conclusionA-CXL with extended riboflavin exposure was effective in stabilizing both tomographic and biomechanical parameters which resulted in increased corneal stiffness and maintained stability. All KC stages demonstrated corneal stability following A-CXL.
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