Trial reportBMC emergency medicine2025
Comparison of positive expiratory pressure device versus non-invasive ventilation on outcomes in acute exacerbation of chronic obstructive pulmonary disease in the emergency department.
Trial report in BMC emergency medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06561464 (Reflections of Oxygen Delivery Methods Applied in Acute Exacerbations of Chronic Obstructive Pulmonary Disease), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Reflections of Oxygen Delivery Methods Applied in Acute Exacerbations of Chronic Obstructive Pulmonary Disease (COPD) on Blood Gas and Spirometer Measurements
Who cites it
1 citing paper in PubMed.
- Effect of the EzPAP system on tidal volume and airway pressures in healthy adults.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute exacerbations of chronic obstructive pulmonary disease (COPD) are among the most common reasons for emergency department visits. In patients who develop hypercapnic respiratory failure, non-invasive mechanical ventilation (NIV) is generally the preferred treatment. However, in overcrowded emergency departments, the number of mechanical ventilation devices may be insufficient. In such situations, positive expiratory pressure (PEP) devices can be utilized. This study aims to evaluate the clinical efficacy of the PEP device (EzPAP
methodsThis prospective, randomized controlled study was conducted on 103 patients who presented to the emergency department with exacerbations of COPD and acute hypercapnic respiratory failure between November 2023 and April 2024. Patients were divided into two groups: EzPAP
resultsA total of 103 patients were included in the study (N: 49, E: 54). In Group N, no statistically significant increase was observed in FEV₁ and FVC after treatment (p = 0.120). A statistically significant increase in FEV₁ and FVC was detected in the EzPAP group (p < 0.001). An increase in oxygen saturation and an improvement in PaCO₂ and lactate levels were observed in both groups (p < 0.001). The difference in blood gas values before and after treatment (delta = Δ) was not statistically significant between the two groups. However, ΔFEV₁ and ΔFVC were significantly higher in the EzPAP group compared to the NIV group (p = 0.007, p = 0.022). The hospital admission rate was higher in the NIV group than in the EzPAP
conclusionEzPAP
trial registrationClinicalTrials Number: NCT06561464 Registration Date: 07/08/2024.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.