Evidence map›Paper›PMID 40596839›Full record

ArticleJournal of neurodevelopmental disorders2025

Pathways to autism diagnosis in adulthood.

Isabelle Dufour, Yohann Chiu, Sébastien Brodeur, Mireille Courteau, Josiane Courteau, Émilie Dubé, Alain Lesage, Éric Fombonne, Mélanie Couture

Abstract read
In one paragraph

Article in Journal of neurodevelopmental disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Isabelle DufourÉcole des Sciences Infirmières, Faculté de Médecine et des Sciences de la Santé (FMSS), Université de Sherbrooke, 3001, 12Th Avenue N., Sherbrooke, QC, J1H 5N4, Canada. isabelle.dufour3@usherbrooke.ca.
Yohann ChiuCentre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CRCHUS), Sherbrooke, QC, Canada.
Sébastien BrodeurDépartement de Psychiatrie et Neurosciences, Université Laval, Québec, QC, Canada.
Mireille CourteauCentre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CRCHUS), Sherbrooke, QC, Canada.
Josiane CourteauCentre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CRCHUS), Sherbrooke, QC, Canada.
Émilie DubéÉcole de Réadaptation, Université de Sherbrooke, Sherbrooke, QC, Canada.
Alain LesageDépartement de Psychiatrie et d'addictologie, Université de Montréal, Montréal, QC, Canada.
Éric FombonneDepartment of Psychiatry, School of Medicine, Oregon Health & Science University, Portland, OR, USA.
Mélanie CoutureÉcole de Réadaptation, Université de Sherbrooke, Sherbrooke, QC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study explored Trajectories of Diagnoses (TDs) preceding a first diagnosis of autism in adulthood.

methodsThis retrospective cohort study used health administrative data from Quebec, Canada, and included all adults with a first recorded diagnosis of autism between 2012 and 2017. A TDs was defined as a succession of medical records of psychiatric and/or neurodevelopmental conditions over time. These TDs were retrospectively analyzed from 2002 to 2017, using a state sequence analysis of diagnoses, in order: Autism, Intellectual or developmental disabilities (IDDs), Schizophrenia spectrum disorder (SSD), Bipolar Disorder (BD), Depressive Disorder (DD), Anxiety Disorder (AD), Attention-deficit/hyperactivity disorder (ADHD), and Other psychiatric and/or neurodevelopmental conditions.

resultsThe cohort included 2799 adults with a first recorded diagnosis of autism between 2012 and 2017. Several psychiatric and/or neurodevelopmental conditions were recorded since 2002, including AD (77.5%), DD (58.0%), SSD (49.4%), BD (48.3%), and IDDs (33.2%). Results revealed 5 distinct types of TDs. Types 1 (63.8%), 2 (17.6%) and 3 (6%) represented individuals in younger age groups with similar characteristics but with very different sequences of diagnoses, characterized by mixed diagnoses in type 1, SSD and AD in Type 2, and IDDs, DD, AD, and ADHD in type 3. Types 4 and 5 (9.0% and 3.6%), representing middle-aged/older groups, displayed distinctive TDs associated with high healthcare use, almost entirely associated with SSD (Type 4) and BD (Type 5).

conclusionThis study proposes a complementary examination of the multiple pathways to diagnosis experienced by adults, highlighting the need to address differential diagnosis and co-occurring psychiatric and neurodevelopmental conditions.

Indexed as

Autistic DisorderNeurodevelopmental DisordersAdolescentAdultAgedAttention Deficit Disorder with HyperactivityFemaleHumansMaleMiddle AgedQuebecRetrospective StudiesYoung AdultAutism spectrum disorderHealthcare useMental healthcareNeurodevelopmental disorderPsychiatric disorderState sequence analysis

Identifiers

PMID40596839
PMCPMC12217371

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.