Evidence map›Paper›PMID 40596830›Full record

ArticleBMC genomics2025

Mechanisms underlying the estradiol mediated protection of yak oviduct epithelial cells against ER-Ca

Xiaolin Ye, Meng Wang, Yangyang Pan, Tianhao Li, Jinglei Wang, Ling Zhao, Rui Zhang, Yan Cui, Sijiu Yu

Abstract read
In one paragraph

Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaolin YeCollege of Veterinary Medicine, Gansu Agricultural University, Lanzhou, 730070, China.
Meng WangCollege of Veterinary Medicine, Gansu Agricultural University, Lanzhou, 730070, China.
Yangyang PanCollege of Veterinary Medicine, Gansu Agricultural University, Lanzhou, 730070, China.
Tianhao LiCollege of Veterinary Medicine, Gansu Agricultural University, Lanzhou, 730070, China.
Jinglei WangCollege of Veterinary Medicine, Gansu Agricultural University, Lanzhou, 730070, China.
Ling ZhaoCollege of Veterinary Medicine, Gansu Agricultural University, Lanzhou, 730070, China.
Rui ZhangCollege of Veterinary Medicine, Gansu Agricultural University, Lanzhou, 730070, China.
Yan CuiCollege of Veterinary Medicine, Gansu Agricultural University, Lanzhou, 730070, China. cuiyan@gsau.edu.cn.
Sijiu YuCollege of Veterinary Medicine, Gansu Agricultural University, Lanzhou, 730070, China. sijiuy@126.com.

Funding

Gansu Province key talent project No. 2022RCXM016Gansu Province seed industry research project No. GZGG-2021-1Major science and technology projects of Gansu Province No. 21ZD10NA001National Nature Science Foundation of China No. 32273091
6 · The paper itself

Abstract

backgroundExtreme weather events are occurring with increasing frequency worldwide. Oviduct epithelial cells (OECs), which provide nutrients and a microenvironment critical for reproductive processes such as fertilization and early embryonic development, are vulnerable to extreme hyperthermia climate. Mitigating heat induced damage to yak oviduct epithelial cells (YOECs) may thus contribute to improving reproductive health. Studies have shown that hyperthermia reduces SERCA protein levels, leading to ER-Ca²⁺ dyschondrosteosis and subsequent cellular injury; this phenomenon indicates that ER-Ca imbalance is a critical factor in cellular damage. Estradiol (E

resultsE

conclusionOur research results indicate that E

Indexed as

CalciumEndoplasmic ReticulumEpithelial CellsEstradiolOviductsAnimalsCattleFemaleHot TemperatureProteomicsSarcoplasmic Reticulum Calcium-Transporting ATPasesCalciumEstradiolSarcoplasmic Reticulum Calcium-Transporting ATPasesApoptosisEstradiolInositol 1,4,5–trisphosphate receptorOviduct epithelial cellsYak

Identifiers

PMID40596830
PMCPMC12210435

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.