ArticleScientific reports2025
Lavender Exosome-Like nanoparticles attenuate UVB-Induced Photoaging via miR166-Mediated inflammation and collagen regulation.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Progress, Challenges, and Standardization Pathways in the Isolation and Purification Techniques of Plant-Derived Vesicles.Plants (Basel, Switzerland) · 2026Review
- Past, Present, and Future of Plant-Derived Extracellular Vesicles in Biomedical Applications.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Recent progress of plant-derived extracellular vesicle-like nanoparticles integrated with biomaterials for skin repair.Journal of nanobiotechnology · 2026Review
- Experimental Characterization Combined with Computational Network Analysis of Metabolites Associated with Chrysanthemum morifolium-derived exosome-like Nanoparticles in Predicting Potential AKI-relevant Targets.Cell biochemistry and biophysics · 2026Article
- Mechanistic Insights into Plant-Derived Exosomes, Their Cross-Kingdom Effects, and Potential Biomedical Applications in Skin Wounds Repair.Plants (Basel, Switzerland) · 2026Review
- Comparative analysis of horsetail and lavender-derived nanovesicles in wound healing and antioxidant defense.BMC biotechnology · 2026Article
- Extracellular Vesicles Derived from Natural Biological Resources and Their Potential to Facilitate Skin Regeneration and Rejuvenation.Pharmaceutics · 2026Review
- Plant-Derived Exosome-Like Nanoparticles: Mechanisms of Cross-Kingdom Regulation and Perspectives as Natural Drug Carriers for Disease Treatment.International journal of nanomedicine · 2026Review
- Plant-Derived Extracellular Vesicles for Nanomedicine in Cardiopulmonary Diseases: A Narrative Review.International journal of nanomedicine · 2026Review
- Plant-Derived Exosomes in Aesthetic Medicine.Biomaterials research · 2026Review
- Article
- Plant-derived extracellular vesicle-like nanoparticles: an emerging immunomodulatory strategy for intervertebral disc degeneration.Frontiers in immunology · 2026Review
- The effectiveness and potential regulatory mechanism ofFrontiers in cell and developmental biology · 2026Article
- Plant-Derived Extracellular-Vesicle-Like Particles: Immune Regulation and Disease Therapy.Research (Washington, D.C.) · 2026Review
- Exosome-Mediated Rewiring of Oxidative Stress-Inflammation-ECM Remodeling Axis Mitigates UVB-Triggered Skin Photoaging.International journal of nanomedicine · 2026Review
- Exosomes from Adipose Tissue Mesenchymal Stem Cells, a Preliminary Study for In Vitro and In Vivo Application.Bioengineering (Basel, Switzerland) · 2025Article
- Plant-derived exosome-like nanovesicles: a novel therapeutic perspective for skin diseases.Journal of nanobiotechnology · 2025Review
- Effect of plant-derived exosome-like nanoparticles in ultraviolet-induced skin photoaging.Frontiers in pharmacology · 2025Review
- Traditional Chinese medicine derived exosome-like nanovesicles in wound repair and skin regeneration.Frontiers in cell and developmental biology · 2025Review
- Alpinia zerumbet-Derived Extracellular Vesicles Protect Against UVB-Induced Photoaging by Enhancing Mitochondrial Bioenergetics and Skin Barrier Function.BioFactors (Oxford, England)Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Excessive UVB exposure accelerates skin aging by triggering inflammatory responses and collagen degradation. In recent years, plant-derived extracellular vesicles (PDEVs) have attracted considerable attention for their ability to encapsulate and deliver bioactive molecules, showing therapeutic potential in various fields such as skin care, wound healing, immune regulation, cancer therapy, and drug delivery. In this study, we isolated lavender exosome-like nanoparticles (LELNs) and evaluated their protective effects against UVB-induced skin photoaging. LELNs were purified using differential and sucrose density gradient centrifugation, with characterization through dynamic light scattering (DLS), nanoparticle tracking analysis (NTA), and transmission electron microscopy (TEM). UVB-induced photoaging models were established in HaCaT cells and mice. Treatment with LELNs reduced inflammatory cytokine levels (IL-1β, IL-6, TNF-α) in cell culture supernatants and mouse dorsal skin homogenates. Histopathological staining revealed significant improvements in epidermal thickness, collagen preservation, and overall skin integrity. Through high-throughput small RNA sequencing and transfection of miRNA mimics analysis, we identified key miRNAs in LELNs, particularly cpa-miR166e and zma-miR166h-3p, both of which belonged to the miR166 family and played a critical role in regulating inflammation and collagen metabolism. Functional enrichment analysis indicated that these miRNAs in LELNs were involved in DNA repair, oxidative stress response, and collagen synthesis pathways. Our findings highlight the potential of LELNs as a novel, natural therapeutic strategy for preventing and treating UVB-induced skin photoaging, offering insights into the use of plant-derived extracellular vesicles in dermatological applications.
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