Evidence map›Paper›PMID 40596615›Full record

ArticleScientific reports2025

Effects of ranolazine on angiogenesis and oxidant-antioxidant balance: an in vivo experimental model study.

Fethullah Kayan, Hasan Basri Savas

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Fethullah KayanDepartment of Cardiology, Diyarbakır GaziYaşargil Training and Research Hospital, Kayapınar, Turkey.ORCID http://orcid.org/0000-0002-8875-5672
Hasan Basri SavasFaculty of Medicine, Department of Medical Biochemistry, Mardin Artuklu University, Artuklu, Mardin, Turkey. hasansavas@artuklu.edu.tr.ORCID http://orcid.org/0000-0001-8759-4507

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ranolazine is known for its antiarrhythmic, antianginal, anti-ischemic properties, as well as its favorable effects on glycemic control. This study aimed to evaluate the effects of ranolazine on oxidative-antioxidative balance and angiogenesis using an in vivo experimental model. A total of 40 Ross 308 chick embryos were used and randomly divided into four groups (n = 10 per group). On the eighth day of incubation, vascular density was assessed. Following vascular evaluation, 4-5 mL of albumen was aspirated using a syringe to measure oxidative stress markers. The groups were as follows: Control, Bevacizumab (BC), Ranolazine 10

Indexed as

AntioxidantsNeovascularization, PhysiologicOxidantsOxidative StressRanolazineAngiogenesisAngiogenesis InhibitorsAnimalsBevacizumabChick EmbryoAngiogenesis InhibitorsAntioxidantsBevacizumabOxidantsRanolazineAngiogenesisCoronary artery diseaseMyocardial ischemiaRanolazine

Identifiers

PMID40596615
PMCPMC12215869

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.