Evidence map›Paper›PMID 40596571›Full record

ArticleScientific reports2025

Therapeutic evaluation of Martynia annua derived carbon dots in epileptic Drosophila model.

Megha B Abbigeri, Muskan Khan, Bothe Thokchom, Sapam Riches Singh, Santosh Mallikarjun Bhavi, Sudheendra Rao Kulkarni, B P Harini, G Vidya Sagar Reddy, Chandramohan Govindasamy, Khalid M Almutairi and 1 more

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Megha B AbbigeriDrosophila and Nanoscience Research Laboratory, Department of Applied Genetics, Karnatak University, Dharwad, Karnataka, 580003, India.
Muskan KhanDrosophila and Nanoscience Research Laboratory, Department of Applied Genetics, Karnatak University, Dharwad, Karnataka, 580003, India.
Bothe ThokchomDrosophila and Nanoscience Research Laboratory, Department of Applied Genetics, Karnatak University, Dharwad, Karnataka, 580003, India.
Sapam Riches SinghDrosophila and Nanoscience Research Laboratory, Department of Applied Genetics, Karnatak University, Dharwad, Karnataka, 580003, India.
Santosh Mallikarjun BhaviDrosophila and Nanoscience Research Laboratory, Department of Applied Genetics, Karnatak University, Dharwad, Karnataka, 580003, India.
Sudheendra Rao KulkarniDrosophila and Nanoscience Research Laboratory, Department of Applied Genetics, Karnatak University, Dharwad, Karnataka, 580003, India.
B P HariniDepartment of Zoology, Bangalore University, Bengaluru, Karnataka, India.
G Vidya Sagar ReddyDepartment of Biotechnology, Vikrama Simhapuri University, Nellore, Andhra Pradesh, India.
Chandramohan GovindasamyDepartment of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Khalid M AlmutairiDepartment of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Yarajarla Ramesh BabuDrosophila and Nanoscience Research Laboratory, Department of Applied Genetics, Karnatak University, Dharwad, Karnataka, 580003, India. rameshy@kud.ac.in.

Funding

Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Saudi Arabia RSPD2025R712
6 · The paper itself

Abstract

This study investigates the synthesis and characterization of Carbon dots (MA-CDs) derived from the aqueous extract of Martynia annua and examining their potential effects in an epilepsy model Drosophila melanogaster. Phytochemical analysis confirmed the presence of saponin, terpeniods, and flavanoids in the leaf extract, which facilitated the green synthesis of MA-CDs. Physicochemical characterization revealed an absorbance peak at 326 nm, the mean size of the particle was 3.17 ± 0.16 nm, and moderate stability (-1.6 mV). To assess the therapeutic potential of MA-CDs alongside the antiepileptic drug Carbamazepine (CBZ), we conducted behavioral and cognitive assays in para bang senseless (para

Indexed as

AnticonvulsantsCarbonEpilepsyPlant ExtractsQuantum DotsAnimalsBehavior, AnimalCarbamazepineDisease Models, AnimalDrosophila melanogasterPlant LeavesAnticonvulsantsCarbamazepineCarbonPlant ExtractsCarbamazepineCarbon dotsEpilepsyMartynia annuaPara bang senseless

Identifiers

PMID40596571
PMCPMC12216562

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.