Evidence map›Paper›PMID 40596567›Full record

ArticleScientific reports2025

Clinical profiling of skin microbiome and metabolome during re-epithelialization.

P Bianchi, C Jacques, J Theunis, E L Jamin, C Orlandi, L Cauhape, S Alvarez-Georges, A Alves, A Simcic-Mori, C Lauze and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

P BianchiPierre Fabre Dermo-Cosmetics & Personal Care, Centre R&D Pierre Fabre, Toulouse, 31025, France. pascale.bianchi@pierre-fabre.com.
C JacquesPierre Fabre Dermo-Cosmetics & Personal Care, Centre R&D Pierre Fabre, Toulouse, 31025, France. carine.jacques@pierre-fabre.com.
J TheunisPierre Fabre Dermo-Cosmetics & Personal Care, Centre R&D Pierre Fabre, Toulouse, 31025, France.
E L JaminUMR1331 Toxalim (Research Centre in Food Toxicology), Toulouse University, INRAE, ENVT, INP-Purpan, UPS, Toulouse, 31027, France.
C OrlandiUMR1331 Toxalim (Research Centre in Food Toxicology), Toulouse University, INRAE, ENVT, INP-Purpan, UPS, Toulouse, 31027, France.
L CauhapePierre Fabre Dermo-Cosmetics & Personal Care, Centre R&D Pierre Fabre, Toulouse, 31025, France.
S Alvarez-GeorgesPierre Fabre Dermo-Cosmetics & Personal Care, Centre R&D Pierre Fabre, Toulouse, 31025, France.
A AlvesPierre Fabre Dermo-Cosmetics & Personal Care, Centre R&D Pierre Fabre, Toulouse, 31025, France.
A Simcic-MoriPierre Fabre Dermo-Cosmetics & Personal Care, Centre R&D Pierre Fabre, Toulouse, 31025, France.
C LauzePierre Fabre Dermo-Cosmetics & Personal Care, Centre R&D Pierre Fabre, Toulouse, 31025, France.
E GravierPierre Fabre Dermo-Cosmetics & Personal Care, Centre R&D Pierre Fabre, Toulouse, 31025, France.
F CarballidoMedical Department, Laboratoires Dermatologiques A-Derma, Les Cauquillous, France.
V RibetPierre Fabre Dermo-Cosmetics & Personal Care, Centre R&D Pierre Fabre, Toulouse, 31025, France.
S Bessou-TouyaPierre Fabre Dermo-Cosmetics & Personal Care, Centre R&D Pierre Fabre, Toulouse, 31025, France.
H DuplanPierre Fabre Dermo-Cosmetics & Personal Care, Centre R&D Pierre Fabre, Toulouse, 31025, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated changes in skin microbiome and metabolome linked to wound healing and how these are affected by a formula known to improve re-epithelialization. In a clinical study with 21 subjects, forearm lesions were induced by epidermal laser ablation. The areas were left untreated or treated with the formula. Re-epithelialization was monitored for 18 days. Skin swabs were analyzed for microbiome diversity using 16 S rRNA gene sequence analysis. Selected species analyzed using digital droplet polymerase chain reaction. Metabolomic profiles were analyzed by ultra-high performance liquid chromatography-high-resolution mass spectrometry. Microbiota alpha-diversity (richness and evenness) was markedly reduced by laser ablation and returned to pre-ablation levels on Day 5. Formula application accelerated the re-epithelialization time (RT), which was more efficient for slow healing (RTs of 15-19 days) than quick healing (10-12 day RTs) subjects. The repairing effect was associated with greater microbiota diversity and species-specific growth of commensal bacteria. Levels of several metabolites on untreated skin at the RT and the extent of the impact of the formula were different in slow and quick healers. The formula significantly modified the skin metabolome, whereby metabolites involved in promoting wound healing were increased and metabolites consumed by the commensal bacteria were decreased.

Indexed as

MetabolomeMicrobiotaRe-EpithelializationSkinAdultBacteriaFemaleHumansMaleMetabolomicsMiddle AgedRNA, Ribosomal, 16SSkin MicrobiomeWound HealingRNA, Ribosomal, 16SClinical studyFormulaRhealba oat concentrateSkin metabolomeSkin microbiomeSodium hyaluronateWound healing

Identifiers

PMID40596567
PMCPMC12219420

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.