ArticleScientific reports2025
Chemotherapy treatment alters DNA methylation patterns in the prefrontal cortex of female rat brain.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Chemobrain as a Neuroimmune Syndrome: Mechanisms, Modifiers, and Emerging Multi-Target Therapeutic Strategies.Molecules (Basel, Switzerland) · 2026Review
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Authors and funding
8 authors.
Funding
Abstract
Chemotherapy can cause several long-term side effects that can affect cancer survivors' quality of life-, notably cognitive decline in response to select chemotherapeutic agents. Studies using both human patients and animal models have been employed to determine the regions of the brain that are subject to the most considerable changes, furthermore, elucidating possible molecular mechanisms of chemotherapy-induced cognitive impairment (CICI). However, the reason behind the differences in symptoms and duration of CICI between patients have yet to be identified. This study focused on understanding whether the systemic delivery of doxorubicin and cyclophosphamide (AC chemotherapeutics) causes any epigenetic factors to change in the female rat prefrontal cortex (PFC), possibly providing an insight into the variability of clinical manifestations of CICI. We evaluated DNA methylation levels and patterns in the PFC after AC-chemotherapy administration. We also demonstrated changes in histone deacetylase and acetyl transferase activity levels in the murine PFC in response to treatment. Despite no change in the global DNA methylation level, we found that several genes related to neuronal development and maintenance were differentially methylated in the promoter and exon regions in the rat PFC. Our study showed a significant increase in the expression of the de novo DNA methyl transferase DNMT3a compared to the control.
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Registered trials
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