ArticleScientific reports2025
The impact of oxidative stress on symptoms associated with multiple sclerosis.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between Mediterranean Diet and Development of Multiple Sclerosis: A Systematic Review and Meta-Analysis.Brain and behavior · 2026Pooled it
- Resistance training improves functional capacities in women with multiple sclerosis: a randomized control trial.BMC neurology · 2024Trial
- Oxidative stress, depressive symptoms, disability, cognitive outcomes and hand dexterity in relapsing-remitting multiple sclerosis patients with mild/moderate disability.IBRO neuroscience reports · 2026Article
- Combined clemastine fumarate and selenomethionine promote remyelination via PI3K/Akt/mTOR signaling in experimental multiple sclerosis.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Dysregulation of the DNA repair‑immune axis: Targeted therapeutic strategies for autoimmune diseases (Review).International journal of molecular medicine · 2026Review
- The correlation between serum markers of oxidative stress and fatigue and related factors in minimally disabled patients with relapsing-remitting multiple sclerosis.Scientific reports · 2026Article
- Article
- Oxidative-Stress-Associated Molecular Signatures in Immune-Mediated Diseases: A Systematic Review Integrating Machine Learning and Systems Biology Approaches.Antioxidants (Basel, Switzerland) · 2026Review
- G‑Quadruplex and i‑Motif Structures in theACS omega · 2026Article
- Bipolar disorder and somatic diseases: Focus on oxidative stress markers.Neuroscience applied · 2026Review
- Neuromodulatory effects of N-acetyl-L-leucine in a human induced neuronal cell culture system.Frontiers in immunology · 2026Article
- Unraveling the Effects ofInternational journal of molecular sciences · 2025Review
- Review
- An Exploratory Cross-Sectional Study of the Association Between Regular Cigarette Smoking and Level of Disability, Hand Dexterity, Cognitive Impairment, Fatigue, and Markers of Oxidative Stress in Male Patients With Relapsing-Remitting Multiple Sclerosis.American journal of men's healthArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple sclerosis (MS) is a chronic, inflammatory and degenerative disease affecting the central nervous system, the pathophysiology of which is unknown. Oxidative stress appears to play a significant role in the initiation and the perpetuation of the inflammatory and neurodegenerative processes associated with MS. We have analysed parameters relating to oxidative stress in people with multiple sclerosis (pwMS) and in healthy individuals.Superoxide dismutase (SOD) activity was higher in pwMS than the control group. Meanwhile, total antioxidant capacity (TAC), 4-hydroxynonenal (4-HNE) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) were lower in pwMS. The TAC levels correlated with age and disease duration. Regarding the relationship with disease activity, SOD levels were related to T2-FLAIR lesion burden in MRI and 8-OHdG to annualised relapse rate. PwMS with slower processing speeds exhibited lower levels of TAC and higher 4-HNE levels. No relationship was found between oxidative stress and the presence of depression, fatigue or quality of life. These results link oxidative stress to the pathogenesis of MS. Our findings suggest that these parameters might vary in function of disease activity or be related to the presence of MS-associated symptoms such as CI.
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