ArticleScientific reports2025
Endothelial cells expressing CPE and vWF are involved in the Immunopathogenesis of primary biliary cholangitis.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Multimodal analysis reveals potential association of CDH13 with endothelial cells and its overexpression in hepatocellular carcinoma.European journal of medical research · 2025Article
- Integrated bioinformatic analysis reveals the underlying mitochondria-associated endoplasmic reticulum membranes-related biomarkers for atrial fibrillation.Frontiers in physiology · 2025Article
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Authors and funding
5 authors.
Funding
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Abstract
Primary biliary cholangitis (PBC) is an immune-mediated, non-suppurative cholestatic liver disease. Liver sinusoidal endothelial cells (LSECs) play a pivotal role in maintaining hepatic immune tolerance. Emerging research indicates that under certain stimuli, LSECs can transition from a tolerogenic to an immunogenic role. We hypothesize that LSECs may be implicated in the pathogenesis of PBC. Single-cell RNA sequencing (scRNA-seq) data were initially analyzed using R statistical software and Cell Ranger. Differentially expressed genes and marker genes were identified using Seurat. Preliminary cell type identification was conducted with SingleR cell clustering. Differential gene expression was determined using t-tests, and significance analysis was performed with the Limma package. Pseudotime analysis was conducted with Monocle2. Compared to the control (CTR) group, the number of endothelial cells in the PBC group was significantly reduced (P < 0.05). Further analysis of these endothelial cells revealed seven distinct subpopulations, including a newly defined CPE
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