ArticleScientific reports2025
Risk factors of sentinel lymph node metastasis in early-stage invasive breast cancer.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Predictors of Sentinel Lymph Node Metastasis and External Validation of the MSKCC Nomogram in Breast Cancer: A Retrospective Single-Center Cohort Study.Diagnostics (Basel, Switzerland) · 2026Article
- Predicting sentinel lymph node metastasis in breast cancer using an interpretable machine learning approach based on multi-domain clinical features.Breast cancer research : BCR · 2026Article
- Breast cancer survival prediction using machine learning and multimodal data for personalized care plan.BMC cancer · 2026Article
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4 authors.
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Abstract
This study aimed to determine the key risk factors affecting sentinel lymph node (SLN) metastasis and to help improve the selection of appropriate candidates for SLN biopsy (SLNB). A total of 2143 cases that underwent SLNB were included. Multivariate analysis included the statistically significant parameters in univariate analysis and revealed the independent risk factors for SLN metastasis: age younger than 40 years old, central tumor location, tumor larger than 3 cm, round-shaped and cortex-thickened axillary lymph node examined by ultrasound, lymphovascular invasion (LVI), and histological classification of invasive breast carcinoma of no special type (IBC-NST) and invasive micropapillary carcinoma (IMPC). The most powerful prognostic factor for SLN metastasis is IMPC (P < 0.001), which increases more than 11 times the risk of SLN positivity. The distance between the tumor and nipple of ≤ 1 cm, LVI, and age younger than 40 years old are also with P value < 0.001. The identification of predictors for SLN metastases based on clinicopathological characteristics could guide the SLNB practice conveniently, especially in less developed areas. Patients with theses revealed adverse features should undergo SLNB with deliberation to avoid a second surgery, particularly when multiple risk factors exist.
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