Evidence map›Paper›PMID 40596146›Full record

ArticleScientific reports2025

Synthesis, in vitro evaluation and computational modelling of benzene sulfonamide derivatives as Dickkopf 1 inhibitors for anticancer drug development.

Muhammad Sajjad Bilal, Syeda Abida Ejaz, Sadia Naseem, Pervaiz Ali Channar, Aamer Saeed, Seema Zargar, Rabail Ujan, Reshma Sahito, Qamar Abbas, Tanveer A Wani

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Muhammad Sajjad BilalDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan.
Syeda Abida EjazDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan. abida.ejaz@iub.edu.pk.
Sadia NaseemDepartment of Chemistry, Quaid-I-Azam University, Islamabad, 45320, Pakistan.
Pervaiz Ali ChannarDepartment of Basic Sciences and Humanities, Faculty of Information Science and Humanities, Dawood University of Engineering and Technology, Karachi, 74800, Pakistan. pervaiz.ali@duet.edu.pk.
Aamer SaeedDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan. asaeed@qau.edu.pk.
Seema ZargarDepartment of Biochemistry, College of Science, King Saud University, P.O.Box 22452, Riyadh, 11451, Saudi Arabia.
Rabail UjanDepartment of MRC, Liaquat University of Medical & Health Sciences, Jamshoro, Pakistan.
Reshma SahitoDepartment of Zoology, University of Sindh, Jamshoro, Pakistan.
Qamar AbbasDepartment of Biology, College of Science, University of Bahrain, Sakhir, 32038, Kingdom of Bahrain.
Tanveer A WaniDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O.Box 2452, Riyadh, 11451, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the modern age of drug discovery sulfanilamide derivatives are known to have great anti-cancerous potential, the current study aimed to synthesize these derivatives in order to evaluate their biological properties against carbonic anhydrase II (CA-II) and Dickkopf - 1(Dkk1) protein which are highly expressed in many cancers including lung cancer. A series of 10 sulfanilamide derivatives was synthesized under controlled conditions using reflux condensation method. Among all the synthesized derivatives (5a-5j), the compound 5d was found to possess highest antioxidant activity (90.7397 ± 0.0732 µg/mL) comparable to vitamin C (95.1571 ± 0.057 µg/mL) and also exhibited maximum inhibition against CA-II with an IC

Indexed as

Antineoplastic AgentsIntercellular Signaling Peptides and ProteinsSulfonamidesAntioxidantsCarbonic Anhydrase IICarbonic Anhydrase InhibitorsDrug DevelopmentHumansMolecular Docking SimulationStructure-Activity RelationshipAntineoplastic AgentsAntioxidantsCarbonic Anhydrase IICarbonic Anhydrase InhibitorsDKK1 protein, humanIntercellular Signaling Peptides and ProteinsSulfonamidesCarbonic anhydrase IIDensity functional theoryDickkopf-1 proteinMolecular DockingSulfanilamide derivatives

Identifiers

PMID40596146
PMCPMC12214485

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