ArticleScientific reports2025
Application of virtual monochromatic images in bone mineral density measurements: a phantom study.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Photon-counting detector CT virtual monoenergetic imaging for bone mineral density quantification: Validation with Micro-CT.iScience · 2026Article
- Precision imaging biomarkers for gout: artifact-specific spectral CT parameters for personalized differentiation of tophi in a prospective study.Therapeutic advances in musculoskeletal disease · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Quantitative CT (QCT) measures bone mineral density (BMD), but beam hardening effect can cause errors and instability in BMD measurements. The purpose of this phantom study is to explore whether the application of virtual monochromatic images (VMIs) in QCT can reduce the measurement error of BMD, and determine the VMI levels that can minimize the error with different radiation doses and regions of interest (ROI) sizes. Utilizing a spine phantom with established hydroxyapatite concentrations, we performed scans with a CT scanner employing rapid tube voltage switching in both single-energy and dual-energy modes. A range of radiation doses (12 mGy, 15 mGy, and 24.4 mGy) was administered, and dual-energy data were reconstructed into VMIs spanning 60-76 keV in 1-keV increments. BMD was measured using regions of interest (ROIs) of varying sizes, and measurements were systematically recorded and compared across all protocols. Our findings indicate that both radiation doses and ROI sizes significantly impacted BMD measurements (P < 0.001). Importantly, BMD values exhibited a consistent decline with increasing VMI levels (r
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.