ArticleScientific reports2025
Metabolic and hormonal effects of an 8 days water only fasting combined with exercise in middle aged men.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Duration-dependent effects of water-only fasting on blood lipids: a systematic review, meta-analysis, and threshold meta-regression.Frontiers in nutrition · 2026Pooled it
- Beneficial Outcome Pathways: A New Mechanistic Framework to Map the Health Effects of Fasting in Metabolic Dysfunction-Associated Steatotic Liver Disease.Journal of nutrition and metabolism · 2026Review
- Nutritional timing and stress biology: intermittent fasting as a hormetic signal for adaptation.Frontiers in nutrition · 2026Review
- Quantity-effect correlation between water intake and serum uric acid in US adults: a cross-sectional study based on NHANES data.Translational andrology and urology · 2025Article
- Endocrine Adaptations to Prolonged Fasting: From Physiology, Clinical Uncertainties, Translational Challenges to Healthspan Implications.Nutrients · 2025Review
- Metabolic stress and muscle mechanics: Acute response of isolated soleus and EDL muscles to prolonged fasting in mice with distinct muscle phenotypes.Biology open · 2025Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Optimal nutrition and physical activity are vital for enhancing physical performance and preventing metabolic diseases like obesity. Recently, interest has grown in long-term fasting, particularly water-only fasting, which involves no food intake and unlimited water consumption. Our study investigated the effects of 8 days of water-only fasting combined with aerobic exercise in 13 middle-aged men, focusing on metabolic, hormonal, and immune changes. Results showed that fasting had a more significant impact than exercise, leading to changes in glucose, uric acid, IGF-1, IGF-2, GH, leptin, and cortisol, improved total antioxidant status (TAS), and reduced lipid peroxidation. While exercise enhanced the effects of fasting on triglycerides, insulin, GH, TAS, PerOX, and IL-6, changes in total protein and lactate were solely due to exercise. Overall, combining fasting and exercise led to a metabolic shift from carbohydrates to fatty acids and hormonal adaptations to stress. These results, although derived from a small group of patients, offer a promising outlook for further research into the effects of fasting combined with physical activity on health and weight maintenance.
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