Evidence map›Paper›PMID 40595937›Full record

ArticleScientific reports2025

Optimization of lipase activity in Aspergillus niger C2J6 whole cells using choline chloride ethylene glycol deep eutectic solvent.

Qingxiu Ma, Mingxiang Tang, Yinsong Wan, Mengzhen Zhang, Qian Mu, Haiyan Yan, Ya Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Qingxiu Ma *School of Food Science, Shihezi University, No. 211, North 4th Road, Shihezi, 832003, Xinjiang Autonomous Region, China.
Mingxiang Tang *School of Food Science, Shihezi University, No. 211, North 4th Road, Shihezi, 832003, Xinjiang Autonomous Region, China.
Yinsong WanSchool of Food Science, Shihezi University, No. 211, North 4th Road, Shihezi, 832003, Xinjiang Autonomous Region, China.
Mengzhen ZhangSchool of Food Science, Shihezi University, No. 211, North 4th Road, Shihezi, 832003, Xinjiang Autonomous Region, China.
Qian MuSchool of Food Science, Shihezi University, No. 211, North 4th Road, Shihezi, 832003, Xinjiang Autonomous Region, China.
Haiyan YanSchool of Food Science, Shihezi University, No. 211, North 4th Road, Shihezi, 832003, Xinjiang Autonomous Region, China.
Ya LiuSchool of Food Science, Shihezi University, No. 211, North 4th Road, Shihezi, 832003, Xinjiang Autonomous Region, China. L68274609@shzu.edu.cn.

Funding

National Natural Science Foundation of China 32060527
6 · The paper itself

Abstract

Deep eutectic solvents (DES), recognized as tunable green solvents, show significant potential for enhancing enzyme activity in biocatalytic applications. This study investigated the effect of choline chloride-ethylene glycol DES on the lipase activity of Aspergillus niger C2J6 whole cells, employing a self-isolated endophytic strain. By varying the molar ratio (1:2-1:4) and water content (0-80%), the highest lipase activity (142.31%) was observed at a 1:1.55 molar ratio with 46% water content. The effects of changes in the composition of DES on its main physicochemical properties (including surface tension, conductivity, density, viscosity, refractive index, polarity, and water activity) were investigated to reveal the intrinsic reasons for the influence of solvents on the relative enzyme activity of lipase. Mathematical models were developed to connect DES composition with key properties. Statistical analysis revealed that among the physicochemical properties of DES, polarity exhibited the most significant impact on enzymatic activity, followed by viscosity, surface tension, and conductivity. This study provides valuable insights for designing optimized DES systems to improve biocatalytic efficiency and precision.

Indexed as

Aspergillus nigerCholineDeep Eutectic SolventsEthylene GlycolLipaseSolventsViscosityCholineDeep Eutectic SolventsEthylene GlycolLipaseSolventsCausal inferenceDeep eutectic solventEnzyme activityLipasePhysicochemical properties

Identifiers

PMID40595937
PMCPMC12217086

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.