ArticleScientific reports2025
Metabolic features of patients with repeated Omicron infections highlight new targets for therapeutic intervention.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Emerging evidence underscores the role of metabolites in immunomodulation. We surmise that specific metabolic signatures might be conserved during repeated Omicron infections. To verify our hypothesis, patients with first (n = 28) and repeated Omicron infections (n = 38) between November 2023 to April 2024 were recruited into this study. Healthy controls (n = 20) were enrolled in the same period. Comprehensive serum metabolome and lipidome were quantitated using mass spectrometric approaches. The neutralizing activity of sera against the pseudotyped Omicron variant JN.1 was determined. Circulating cytokines/chemokines were quantified using a Bioplex Kit Assay. The proportion of severe/moderate infections was 2.9-fold higher in first infection patients compared to reinfection patients (67.9% vs. 23.7%, p = 0.004). Geometric mean titers (GMT) for the Omicron variant JN.1 were higher in moderate/severe infections than mild infections, but non-significant between first and repeated infections. We observed perturbed coregulation between plasma indoles and circulating plasmalogen phospholipids in Omicron-infected patients, while disrupted histidine-triacylglycerol coregulation was specific to first-infections. A panel of three lasso-selected metabolites (SL d18:1/22:0 h, tetra-peptide Pro Tyr Tyr Val, and 1,2,3,4-Tetrahydroisoquinoline) effectively differentiated moderate/severe Omicron infections from mild ones (AUROC at 0.917, 95% CI 0.793-1.000). Our findings highlight modifiable metabolic signatures as possibly new therapeutic interventions against rapidly evolving variants of SARS-CoV-2.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.