Evidence map›Paper›PMID 40595777›Full record

ArticleScientific reports2025

Association between maternal folate levels and febrile seizures in early childhood from the Japan Environment and Children's Study.

Sachi Tokunaga, Hideki Shimomura, Masumi Okuda, Yohei Taniguchi, Naoko Taniguchi, Tetsuro Fujino, Masayuki Shima, Yasuhiro Takeshima, Japan Environment and Children’s Study (JECS) Group

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Sachi TokunagaDepartment of Pediatrics, School of Medicine, Hyogo Medical University, 1-1, Mukogawa, Nishinomiya, Hyogo, 663-8501, Japan.
Hideki ShimomuraDepartment of Pediatrics, School of Medicine, Hyogo Medical University, 1-1, Mukogawa, Nishinomiya, Hyogo, 663-8501, Japan. simo-ped@hyo-med.ac.jp.
Masumi OkudaDepartment of Pediatrics, School of Medicine, Hyogo Medical University, 1-1, Mukogawa, Nishinomiya, Hyogo, 663-8501, Japan.
Yohei TaniguchiDepartment of Pediatrics, School of Medicine, Hyogo Medical University, 1-1, Mukogawa, Nishinomiya, Hyogo, 663-8501, Japan.
Naoko TaniguchiDepartment of Pediatrics, School of Medicine, Hyogo Medical University, 1-1, Mukogawa, Nishinomiya, Hyogo, 663-8501, Japan.
Tetsuro FujinoDepartment of Pediatrics, School of Medicine, Hyogo Medical University, 1-1, Mukogawa, Nishinomiya, Hyogo, 663-8501, Japan.
Masayuki ShimaHyogo Regional Center for the Japan Environmental and Children's Study, Hyogo Medical University, Nishinomiya, Hyogo, Japan.
Yasuhiro TakeshimaDepartment of Pediatrics, School of Medicine, Hyogo Medical University, 1-1, Mukogawa, Nishinomiya, Hyogo, 663-8501, Japan.
Japan Environment and Children’s Study (JECS) Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The relationship between maternal serum folate levels during pregnancy and febrile seizures (FS) in offspring remains unclear. This study assessed the association between maternal serum folate levels during late pregnancy and initial incidence of FS at 0-12, 13-24, and 25-36 months of age, using data from the Japan Environment and Children's Study, a nationwide birth cohort study. Among 100,303 live birth records, 92,129 were reviewed. The results revealed that maternal serum folate levels in the fourth quartile (Q4) were associated with a significantly lower incidence of FS at 0-12 months of age compared with the reference quartile (Q1) (odds ratio [OR]: 0.71; 95% confidence interval [CI]: 0.59-0.87). However, at 25-36 months of age, maternal serum folate levels in Q4 were associated with a significantly higher incidence of FS than in Q1 (OR: 1.18; 95% CI: 1.00-1.38). No correlation was observed at13-24 months of age. These findings suggest that high maternal serum folate levels during late pregnancy might delay initial incidence of FS, reducing this initial incidence of FS at 0-12 months of age and increasing it at 25-36 months of age.

Indexed as

Folic AcidPrenatal Exposure Delayed EffectsSeizures, FebrileAdultChild, PreschoolFemaleHumansIncidenceInfantInfant, NewbornJapanMalePregnancyFolic AcidFebrile seizureFolateFolic acid supplementationNeural tube defects

Identifiers

PMID40595777
PMCPMC12215610

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