Evidence map›Paper›PMID 40595543›Full record

ArticleNature communications2025

Immunomics-guided biomarker discovery for human liver fluke infection and infection-associated cholangiocarcinoma.

Lakkhana Sadaow, Rutchanee Rodpai, Michael J Smout, Rie Nakajima, Patcharaporn Boonroumkaew, Javier Sotillo, Bemnet A Tedla, Vor Luvira, Amnat Kitkhuandee, Krisada Paonariang and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Lakkhana Sadaow *Department of Parasitology, Faculty of Medicine, and Mekong Health Science Research Institute, Khon Kaen University, Khon Kaen, Thailand.
Rutchanee Rodpai *Department of Parasitology, Faculty of Medicine, and Mekong Health Science Research Institute, Khon Kaen University, Khon Kaen, Thailand.
Michael J Smout *Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, Australia.ORCID http://orcid.org/0000-0001-6937-0112
Rie Nakajima *Vaccine R&D Center, Department of Physiology and Biophysics, University of California Irvine, Irvine, CA, USA.
Patcharaporn BoonroumkaewDepartment of Parasitology, Faculty of Medicine, and Mekong Health Science Research Institute, Khon Kaen University, Khon Kaen, Thailand.
Javier SotilloParasitology Reference and Research Laboratory, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.ORCID http://orcid.org/0000-0002-1443-7233
Bemnet A TedlaAustralian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, Australia.
Vor LuviraDepartment of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Amnat KitkhuandeeDepartment of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Krisada PaonariangDepartment of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Wattana SukeepaisarnjaroenDepartment of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Hiroshi YamasakiDepartment of Parasitology, National Institute of Infectious Diseases, Tokyo, Japan.
Sutas SuttiprapaTropical Disease Research Center, Department of Tropical Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Thewarach LahaDepartment of Parasitology, Faculty of Medicine, and Mekong Health Science Research Institute, Khon Kaen University, Khon Kaen, Thailand.
Banchob SripaTropical Disease Research Center, Department of Tropical Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Rafael de AssisVaccine R&D Center, Department of Physiology and Biophysics, University of California Irvine, Irvine, CA, USA.
Aarti JainVaccine R&D Center, Department of Physiology and Biophysics, University of California Irvine, Irvine, CA, USA.
Wannaporn IttiprasertDepartment of Microbiology, Immunology and Tropical Medicine, School of Medicine and Health Sciences, George Washington University, Washington, DC, USA.
Victoria H MannDepartment of Microbiology, Immunology and Tropical Medicine, School of Medicine and Health Sciences, George Washington University, Washington, DC, USA.
Yide WongAustralian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, Australia.
Philip L FelgnerVaccine R&D Center, Department of Physiology and Biophysics, University of California Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-4117-8505
Wanchai MaleewongDepartment of Parasitology, Faculty of Medicine, and Mekong Health Science Research Institute, Khon Kaen University, Khon Kaen, Thailand.
Paul J BrindleyDepartment of Microbiology, Immunology and Tropical Medicine, School of Medicine and Health Sciences, George Washington University, Washington, DC, USA. pbrindley@gwu.edu.ORCID http://orcid.org/0000-0003-1765-0002
Alex LoukasAustralian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, Australia. alex.loukas@jcu.edu.au.ORCID http://orcid.org/0000-0002-0896-8441
Pewpan M IntapanDepartment of Parasitology, Faculty of Medicine, and Mekong Health Science Research Institute, Khon Kaen University, Khon Kaen, Thailand.

Funding

Targeting parasite-host communication to combat liver fluke-induced bile duct cancerR01CA164719 · NCI · GEORGE WASHINGTON UNIVERSITY · PI Paul J Brindley, THEWARACH LAHA · 2012 to 2026
$5.0M
Department of Health | National Health and Medical Research Council (NHMRC) 2008450National Research Council of Thailand (NRCT) N42A670561NCI NIH HHS R01 CA164719
6 · The paper itself

Abstract

Sensitive diagnostics are needed to improve management and surveillance of opisthorchiasis and opisthorchiasis-associated cholangiocarcinoma (CCA) throughout East Asia. Herein we generate and screen an Opisthorchis viverrini recombinant secreted proteome to identity antibody biomarkers of liver fluke infection and CCA with sera from study participants in endemic populations and evaluate their utility as point-of-care immunochromatographic tests (PoC-ICTs). We incorporate two of the most promising antigens from the proteome array screen, P1 and P9, into PoC-ICTs to further validate their diagnostic performance. The P9-IgG4 PoC-ICT is superior amongst the single recombinant antigen tests for diagnosing fluke infection as well as fluke-induced CCA, and out-performs parasite crude extract-IgG ICTs. Here we identify two biomarkers of O. viverrini infection and infection-associated CCA that could form the basis of novel antibody serodiagnostic tests for human liver fluke infection and associated cancer.

Indexed as

Bile Duct NeoplasmsCholangiocarcinomaFascioliasisOpisthorchiasisOpisthorchisAnimalsAntibodies, HelminthAntigens, HelminthBiomarkersFasciola hepaticaFemaleHumansImmunoglobulin GMaleProteomeAntibodies, HelminthAntigens, HelminthBiomarkersImmunoglobulin GProteome

Identifiers

PMID40595543
PMCPMC12218120

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.