ArticleNature communications2025
Reduction of neuronal activity mediated by blood-vessel regression in the adult brain.
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Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16citing papers in PubMed
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Who cites it
16 citing papers in PubMed.
- A targeted vector for brain endothelial cell gene delivery and cerebrovascular malformation modelling.Nature biomedical engineering · 2026Article
- Cellular and signalling mechanisms that regulate the blood-brain barrier.Nature reviews. Molecular cell biology · 2026Review
- Glial heterogeneity shapes region-specific angiogenesis and neurovascular integrity in the CNS.Science advances · 2026Article
- Degeneration of Interpericyte Tunneling Nanotubes Can Occur in the Absence of Pericyte Loss in Diabetic Retina Disease.Investigative ophthalmology & visual science · 2026Article
- Glioma-Associated Microglia Augment Neuronal Hyper-Excitability in Glioma.Brain tumor research and treatment · 2026Review
- Brain endothelial GαEBioMedicine · 2026Article
- Vascular Aging.Circulation · 2026Review
- Cerebral capillary computation.American journal of physiology. Cell physiology · 2026Review
- Astrocytes: Orchestrators of brain gas exchange and oxygen homeostasis.The Journal of physiology · 2026Review
- Cholesterol and docosahexaenoic acid likely protect against alcohol-induced constriction of cerebral arteries via a common pathway.Advances in drug and alcohol research · 2026Article
- Aging Rewires Neuronal Metabolism, Exacerbating Cell Death After Ischemic Stroke: A Hidden Reason for the Failure of Neuroprotection.International journal of molecular sciences · 2025Article
- Walking on the tightrope: the shared roles of the bridging pericytes in the brain.Frontiers in cellular neuroscience · 2025Review
- Endothelial Piezo1 channel mediates mechano-feedback control of brain blood flow.Nature communications · 2024Article
- A systematic observation of vasodynamics from different segments along the cerebral vasculature in the penumbra zone of awake mice following cerebral ischemia and recanalization.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Capillary pruning couples tissue perfusion and oxygenation with cardiomyocyte maturation in the postnatal mouse heart.Frontiers in cell and developmental biology · 2023Article
- Physiological and Pathological Remodeling of Cerebral Microvessels.International journal of molecular sciences · 2022Review
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Authors and funding
49 authors.
Xiaofei Gao *Children's Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Xing-Jun Chen *Chinese Institute for Brain Research, Beijing, Beijing, 102206, China.ORCID http://orcid.org/0009-0004-7657-6070
Meng YeChinese Institute for Brain Research, Beijing, Beijing, 102206, China.
Jun-Liszt LiChinese Institute for Brain Research, Beijing, Beijing, 102206, China.
Nannan LuChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.ORCID http://orcid.org/0000-0003-0905-8199
Di YaoChinese Institute for Brain Research, Beijing, Beijing, 102206, China.
Bo CiChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Fei ChenChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.ORCID http://orcid.org/0009-0005-5378-7606
Lijun ZhengChinese Institute for Brain Research, Beijing, Beijing, 102206, China.
Yating YiState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Shiwen ZhangState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Zhanying BiChinese Institute for Brain Research, Beijing, Beijing, 102206, China.
Xinwei GaoChinese Institute for Brain Research, Beijing, Beijing, 102206, China.
Yuanlei YueGW Institute for Neuroscience, the George Washington University, Washington, DC, 20037, USA.ORCID http://orcid.org/0000-0002-0552-2911
Tingbo LiInstitute of Basic Medical Sciences, Westlake Institute for Advanced Study, Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou, 310024, China.
Jiafu LinDepartment of Medical College, Fujian Health College, Fuzhou, 350101, China.
Ying-Chao ShiGuangdong Institute of Intelligence Science and Technology, Guangdong, 519031, China.
Kaibin ShiDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University; Chinese Institutes for Medical Research, Beijing, 100069, China.
Nicholas E PropsonHuffington Center on Aging, Baylor College of Medicine, Houston, TX, 77030, USA.
Yubin HuangShenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Katherine PoinsatteDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX75390, USA.
Zhaohuan ZhangChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Dale B BoscoDepartment of Neurology, Mayo Clinic, Rochester, MN, 55905, USA.
Shi-Bing YangDepartments of Physiology, Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA, 94158, USA.ORCID http://orcid.org/0000-0001-8061-3963
Ralf H AdamsDepartment of Tissue Morphogenesis, Max-Planck-Institute for Molecular Biomedicine, and Faculty of Medicine, University of Münster, D-, 48149, Münster, Germany.ORCID http://orcid.org/0000-0003-3031-7677
Volkhard LindnerCenter for Molecular Medicine, MaineHealth Institute for Research, Scarborough, ME04074, USA.
Fen HuangDepartments of Physiology, Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA, 94158, USA.
Long-Jun WuDepartment of Neurology, Mayo Clinic, Rochester, MN, 55905, USA.
Hui ZhengHuffington Center on Aging, Baylor College of Medicine, Houston, TX, 77030, USA.ORCID http://orcid.org/0000-0002-5427-3798
Simon HippenmeyerInstitute of Science and Technology Austria, Am Campus 1, 3400, Klosterneuburg, Austria.ORCID http://orcid.org/0000-0003-2279-1061
Ann M StoweDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX75390, USA.ORCID http://orcid.org/0000-0001-8111-4429
Bo PengDepartment of Neurosurgery, Huashan Hospital, Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai, 200040, China.ORCID http://orcid.org/0000-0003-4183-5939
Marta MargetaDepartment of Pathology, University of California at San Francisco, San Francisco, CA, 94143, USA.ORCID http://orcid.org/0000-0001-6889-2488
Qingchun GuoChinese Institute for Brain Research, Beijing, Beijing, 102206, China.
Xiaoqun WangChangping Laboratory, Beijing, 102206, China.ORCID http://orcid.org/0000-0003-3440-2617
Qiang LiuDepartment of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Jakob KörbelinDepartment of Oncology, Hematology and Bone Marrow Transplantation, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.ORCID http://orcid.org/0000-0002-5435-7182
Martin TrepelDepartment of Hematology and Clinical Oncology, University Medical Center and Medical Faculty Augsburg University, Augsburg, 86156, Germany.
Hui LuDepartment of Pharmacology and Physiology, School of Medicine and Health Sciences, the George Washington University, Washington, DC, 20037, USA.ORCID http://orcid.org/0000-0003-2336-2170
Guoen CaiDepartment of Medical College, Fujian Health College, Fuzhou, 350101, China.ORCID http://orcid.org/0000-0002-0264-2125
Bo O ZhouKey Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai, 200031, China.ORCID http://orcid.org/0000-0001-8950-8799
Bo ShenNational Institute of Biological Sciences, Beijing (NIBS), 102206, Beijing, China.
Ying-Mei LuKey Laboratory of Modern Toxicology of Ministry of Education; School of Basic Medical Sciences, Nanjing Medical University, Nanjing, 211166, China.
Wenzhi SunChinese Institute for Brain Research, Beijing, Beijing, 102206, China.ORCID http://orcid.org/0000-0001-9282-9526
Jie-Min JiaInstitute of Basic Medical Sciences, Westlake Institute for Advanced Study, Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou, 310024, China.
Feng HanMedical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education, China; International Joint Laboratory for Drug Target of Critical Illnesses, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China.ORCID http://orcid.org/0000-0002-4868-3491
Hu ZhaoChinese Institute for Brain Research, Beijing, Beijing, 102206, China.
Robert M BachooDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX75390, USA.
Woo-Ping GeChinese Institute for Brain Research, Beijing, Beijing, 102206, China. woopingge@cibr.ac.cn.ORCID http://orcid.org/0000-0001-8219-1055
Funding
UT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI MELANIE H. COBB · 2010 to 2026
$53.7MKnockin Mouse Models of Alzheimers DiseaseR01AG020670 · NIA · BAYLOR COLLEGE OF MEDICINE · PI Hui Zheng · 2002 to 2026
$9.1MDecoding the role of diverse astrocyte populations in aging and ADRF1AG054111 · NIA · BAYLOR COLLEGE OF MEDICINE · PI DENEEN, BENJAMIN, ZHENG, HUI · 2016 to 2016
$3.1MB Cells Directly Alter Adaptive Plasticity to Support Functional Recovery After StrokeR01NS088555 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI STOWE, ANN MARIE · 2015 to 2025
$2.8MUnderstanding the effects of motor learning in wild-type and Mecp2-deficient miceR01NS118197 · NINDS · GEORGE WASHINGTON UNIVERSITY · PI Hui Lu · 2022 to 2026
$2.3MDiversity Supplement: B Cells Directly Alter Adaptive Plasticity to Support Functional Recovery After StrokeRF1NS088555 · NINDS · UNIVERSITY OF KENTUCKY · PI STOWE, ANN MARIE · 2021 to 2023
$1.3MNational Natural Science Foundation of China (National Science Foundation of China) 32170964NCI NIH HHS P30 CA142543NIA NIH HHS R01 AG020670NIA NIH HHS RF1 AG054111NINDS NIH HHS R01 NS088555NINDS NIH HHS R01 NS118197NINDS NIH HHS RF1 NS088555
Abstract
The brain vasculature supplies neurons with glucose and oxygen, but little is known about how vascular plasticity contributes to brain function. Using longitudinal in vivo imaging, we report that a substantial proportion of blood vessels in the adult mouse brain sporadically occlude and regress. Their regression proceeds through sequential stages of blood-flow occlusion, endothelial cell collapse, relocation or loss of pericytes, and retraction of glial endfeet. Regressing vessels are found to be widespread in mouse, monkey and human brains. We further reveal that blood vessel regression cause a reduction of neuronal activity due to a dysfunction in mitochondrial metabolism and glutamate production. Our results elucidate the mechanism of vessel regression and its role in neuronal function in the adult brain.
Indexed as
Blood VesselsBrainNeuronsAnimalsCerebrovascular CirculationEndothelial CellsFemaleGlutamic AcidHumansMaleMiceMice, Inbred C57BLMitochondriaPericytesGlutamic Acid
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