Evidence map›Paper›PMID 40595448›Full record

ArticleScientific reports2025

Control of motor coordination by transient receptor potential melastatin 8 through γ-aminobutyric acidergic circuit modulation in the male mouse cerebellum.

Mayuka Koyama, Koki Harada, Naoko Takizawa, Shinji Kobuchi, Miwa Kambara, Hikaru Tanaka, Riona Araki, Yuri Yamada, Yukako Ito, Kazuyuki Takata and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mayuka Koyama *Division of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan.
Koki Harada *Joint Research Laboratory, Division of Integrated Pharmaceutical Sciences, Kyoto Pharmaceutical University, Kyoto, Japan.
Naoko TakizawaDivision of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan.
Shinji KobuchiDepartment of Pharmacokinetics, Kyoto Pharmaceutical University, Kyoto, Japan.
Miwa KambaraLaboratory of Pathophysiology, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kodo, Kyotanabe, Kyoto, 610-0395, Japan.
Hikaru TanakaDivision of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan.
Riona ArakiJoint Research Laboratory, Division of Integrated Pharmaceutical Sciences, Kyoto Pharmaceutical University, Kyoto, Japan.
Yuri YamadaJoint Research Laboratory, Division of Integrated Pharmaceutical Sciences, Kyoto Pharmaceutical University, Kyoto, Japan.
Yukako ItoDepartment of Pharmacokinetics, Kyoto Pharmaceutical University, Kyoto, Japan.
Kazuyuki TakataJoint Research Laboratory, Division of Integrated Pharmaceutical Sciences, Kyoto Pharmaceutical University, Kyoto, Japan.
Shinichi KatoDivision of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan.
Kenjiro MatsumotoDivision of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan. k-matsumoto@dwc.doshisha.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transient receptor potential melastatin 8 (TRPM8) is a non-selective cation channel that is activated by mild cooling and chemical agents. Although TRPM8 is widely expressed in the peripheral and central nervous systems, its cerebellar distribution and functional significance remain unexplored. We investigated the expression and role of TRPM8 in motor function using TRPM8-enhanced green fluorescent protein and TRPM8-deficient (TRPM8KO) mice. TRPM8 immunoreactivity was observed in parvalbumin- and vesicular γ-aminobutyric acid (GABA) transporter-labeled interneurons. TRPM8 was also expressed in hyperpolarization-activated cyclic nucleotide-gated potassium channel 1-labeled inhibitory plexuses that enveloped GABA

Indexed as

Cerebellumgamma-Aminobutyric AcidMotor ActivityTRPM Cation ChannelsAnimalsInterneuronsMaleMiceMice, KnockoutPurkinje CellsReceptors, GABA-Agamma-Aminobutyric AcidReceptors, GABA-ATRPM8 protein, mouseTRPM Cation ChannelsCerebellumGABAInterneuronMotor coordinationRotarod testTransient receptor potential melastatin 8

Identifiers

PMID40595448
PMCPMC12219325

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.