Evidence map›Paper›PMID 40595425›Full record

ArticleCommunications medicine2025

Variants of β-lactamase-encoding genes are disseminated by multiple genetically distinct lineages of bloodstream Escherichia coli.

Stephanie S R Souza, Kathryn R Piper, Odion O Ikhimiukor, Michael M Marcovici, Nicole I Zac Soligno, Ashley J Harmon, Elissa M Eckhardt, Nisalda Carreiro, Adrienne A Workman, Isabella W Martin and 1 more

Abstract read
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In one paragraph

Article in Communications medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Stephanie S R SouzaDepartment of Biological Sciences, University at Albany, State University of New York, Albany, NY, USA.ORCID http://orcid.org/0000-0002-4207-8231
Kathryn R PiperDepartment of Biological Sciences, University at Albany, State University of New York, Albany, NY, USA.
Odion O IkhimiukorDepartment of Biological Sciences, University at Albany, State University of New York, Albany, NY, USA.
Michael M MarcoviciDepartment of Biological Sciences, University at Albany, State University of New York, Albany, NY, USA.
Nicole I Zac SolignoDepartment of Biological Sciences, University at Albany, State University of New York, Albany, NY, USA.
Ashley J HarmonDepartment of Biological Sciences, University at Albany, State University of New York, Albany, NY, USA.
Elissa M EckhardtDartmouth-Hitchcock Medical Center and Dartmouth College Geisel School of Medicine, Lebanon, NH, USA.
Nisalda CarreiroDartmouth-Hitchcock Medical Center and Dartmouth College Geisel School of Medicine, Lebanon, NH, USA.
Adrienne A WorkmanDartmouth-Hitchcock Medical Center and Dartmouth College Geisel School of Medicine, Lebanon, NH, USA.ORCID http://orcid.org/0009-0007-5088-0690
Isabella W MartinDartmouth-Hitchcock Medical Center and Dartmouth College Geisel School of Medicine, Lebanon, NH, USA. isabella.w.martin@hitchcock.org.
Cheryl P AndamDepartment of Biological Sciences, University at Albany, State University of New York, Albany, NY, USA. candam@albany.edu.ORCID http://orcid.org/0000-0003-4428-0924

Funding

Population and evolutionary dynamics of recombining genes and alleles in bacteriaR35GM142924 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI Cheryl Marie P Andam · 2021 to 2026
$1.9M
NIGMS NIH HHS R35 GM142924U.S. Department of Health & Human Services | National Institutes of Health (NIH) R35GM142924
6 · The paper itself

Abstract

backgroundEscherichia coli is a major cause of bloodstream infections (BSI), which can lead to life-threatening organ dysfunction. We determined the genomic characteristics of E. coli implicated in BSI and the spread of antimicrobial resistance (AMR).

methodsWe carried out in vitro antimicrobial susceptibility testing and whole genome sequencing of 557 E. coli isolates recovered from BSI at Dartmouth-Hitchcock Medical Center, USA.

resultsWe identify at least 119 previously recognized sequence types (ST), of which five STs (ST69, ST73, ST95, ST127, ST131) altogether represent 50% of the bloodstream E. coli population. Of the 142 distinct serotypes detected, the most common are O25:H4 and O1:H7. A total of 62 acquired genes are associated with resistance to at least 13 antimicrobial classes. These include the β-lactamase gene families bla

conclusionsMultiple but genetically distinct E. coli lineages similarly cause BSI and shape AMR dissemination, emphasizing the opportunistic nature of E. coli in invasive infections.

Identifiers

PMID40595425
PMCPMC12216325

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.