Evidence map›Paper›PMID 40595381›Full record

ArticleScientific reports2025

Assessment of pit viper associated subclinical myocardial injury by speckle tracking imaging.

Jing Chen, Yang Feng, Jiaqi Chen, Chunmei Yin, Jiaming Xia, Li Fan, Liqun Sun, Chunjiang Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jing ChenDepartment of Ultrasound, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Children's Hospital of Chongqing Medical University, Chongqing, China.
Yang FengDepartment of Ultrasound, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Children's Hospital of Chongqing Medical University, Chongqing, China.
Jiaqi ChenDepartment of Ultrasound, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Children's Hospital of Chongqing Medical University, Chongqing, China.
Chunmei YinDepartment of Ultrasound, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Children's Hospital of Chongqing Medical University, Chongqing, China.
Jiaming XiaDepartment of Ultrasound, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Children's Hospital of Chongqing Medical University, Chongqing, China.
Li FanDepartment of Ultrasound, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Children's Hospital of Chongqing Medical University, Chongqing, China.
Liqun SunDepartment of Pediatrics, Division of Cardiology, The Hospital for Sick Children, University of Toronto, Toronto, Canada.
Chunjiang YangDepartment of Ultrasound, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Children's Hospital of Chongqing Medical University, Chongqing, China. cjyang@hospital.cqmu.edu.cn.

Funding

Chongqing Medical University W0114Joint project of Chongqing Health Commission and Science and Technology Bureau 2023MSXM097
6 · The paper itself

Abstract

In post-snakebite patient care, cardiac function is chiefly monitored through Left Ventricular Ejection Fraction (LVEF) via traditional echocardiography. This approach fails to detect early systolic dysfunction sensitively, which is key for managing envenomation-induced myocardial damage and impacts treatment and prognosis. In a study of 37 snakebite patients, individuals were grouped by severity using the Snakebite Severity Scale (SSS). Correlations between serological markers and two-dimensional speckle tracking echocardiography (2D-STE) strain parameters were analyzed, with ROC curves assessing the diagnostic effectiveness for myocardial injury. After a venomous snakebite, the study found a significant decrease in the left ventricular endocardial global longitudinal strain (GLSendo) compared to the middle and epicardium layer (p < 0.01). The circumferential strain of the apical segment (ACS) was also lower in the affected group than in the control group (p < 0.05), with more severe envenomation associated with a great reduction in both GLSendo and the ACS (p < 0.01). The sensitivity of GLSendo for diagnosing myocardial injury due to venomous snakebite was 0.935, with the cut-off was 18.7%. The finding underscores the importance of using GLSendo as part of the standard echocardiographic assessment in patient. By providing early insight into the extent of myocardial injury and informed decisions regarding treatment and patient management.

Indexed as

EchocardiographySnake BitesAdultAnimalsFemaleHumansMaleMiddle AgedMyocardiumVentricular Dysfunction, LeftVentricular Function, LeftCardiotoxicityLeft ventricular functionMyocardial injurySnake venomSpeckle tracking echocardiography

Identifiers

PMID40595381
PMCPMC12214783

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.