Evidence map›Paper›PMID 40595319›Full record

Observational studyScientific reports2025

Comparative analysis of humoral immunity kinetics following three COVID-19 vaccines in a multi-ethnic cohort of medical students and healthcare professionals across Malaysia.

Ashwathy Varadarajan Thundakattil, Rekha Prabhu, Girish Prabhu, Madhumanti Barman, Muthuvel Mani, Somsubhra De, Htay Lwin, Nelli Giribabu, Sabyasachi Das

Abstract readComparative StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ashwathy Varadarajan ThundakattilDepartment of Physiology, Faculty of Medicine, Manipal University College Malaysia, Melaka, Malaysia.
Rekha PrabhuDepartment of Physiology, Faculty of Medicine, Manipal University College Malaysia, Melaka, Malaysia.
Girish PrabhuDepartment of Biochemistry, Faculty of Medicine, Manipal University College Malaysia, Melaka, Malaysia.
Madhumanti BarmanDepartment of Physiology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Muthuvel ManiDepartment of Anatomy, Faculty of Medicine, Manipal University College Malaysia, Melaka, Malaysia.
Somsubhra DeDepartment of Obstetrics and gynaecology, Faculty of Medicine, Manipal University College Malaysia, Melaka, Malaysia.
Htay LwinDepartment of Community Medicine, Faculty of Medicine, Manipal University College Malaysia, Melaka, Malaysia.
Nelli GiribabuDepartment of Physiology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Sabyasachi DasDepartment of Physiology, Faculty of Medicine, Manipal University College Malaysia, Melaka, Malaysia. sabyasachi.das@um.edu.my.

Funding

Manipal University College Malaysia internal research support grant MUCM/002/2021
6 · The paper itself

Abstract

The objective of our study was to evaluate the time-dependent humoral immunity kinetics among multi-ethnic population of medical students and healthcare professionals across Malaysia following two doses of Comirnaty, Vaxzevria, and CoronaVac vaccines. Prospective observational cohort research was carried out from September 2021-March 2023. 242 vaccine recipients have completed the follow-up. After second vaccination dosage, peripheral blood was drawn every four weeks from week 0-24. Anti-S IgG and percentage of neutralization were measured from each individual plasma sample. Recipients of Comirnaty and Vaxzevria vaccine, exhibited adequate anti-S IgG and neutralizing antibody till week 24. In compared to Comirnaty/Vaxzevria vaccine group, CoronaVac group showed significant decrease of antibody as early as week 12. The Comirnaty vaccine peaked anti-S IgG production at week 4, while the Vaxzevria and CoronaVac vaccines peaked at week 2. The Comirnaty vaccine (91.3%) showed strong Ig-RBD neutralizing antibody response even after week 24, which led to the slowest rate of antibody waning when compared to CoronaVac (13%), which never achieves high Ig-RBD neutralizing antibody. The percentage of inhibition of Ig-RBD binding on ACE

Indexed as

COVID-19COVID-19 VaccinesImmunity, HumoralAdultAntibodies, NeutralizingAntibodies, ViralEthnicityFemaleHealth PersonnelHumansImmunoglobulin GMalaysiaMaleProspective StudiesStudents, MedicalVaccinationAntibodies, NeutralizingAntibodies, ViralCOVID-19 VaccinesImmunoglobulin GComirnaty vaccineComparative antibody responseCoronaVac vaccineEthnicityMalaysiaTime dependent responseVaxzevria vaccineWaning of antibody

Identifiers

PMID40595319
PMCPMC12216813

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.