Trial reportScientific reports2025
A pilot clinical trial to explore the effects of UV exposure on vitamin D synthesis and inflammatory responses in vitamin D-Deficient adults.
Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Vitamin D in Photosynthetic Organisms and Fungi: Sterol Photochemistry, UV-B Availability, and Biofortification Potential.Current issues in molecular biology · 2026Review
- Microbiota and Gut Inflammatory Markers (Zonulin and Fecal Calprotectin) Exhibit Age-Dependent Variation in Patients with Ulcerative Colitis.Life (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
Ultraviolet radiation (UVR) is essential for vitamin D synthesis and influences various biological processes. This study examined the effects of controlled UV exposure on vitamin D synthesis and skin inflammation in healthy adults. In a randomized clinical trial, 24 volunteers received four 5-min standardized UV exposures (UVB: 1.34 mW/cm²; UVA: 27.7 mW/cm²) on representative skin areas. Blood samples were collected before exposure and after every two sessions to assess serum vitamin D, inflammatory markers, vitamin D-related markers, and oxidative stress indicators. Serum vitamin D concentration significantly increased after four exposures (p < 0.001), while calcium, phosphorus, and parathyroid hormone (PTH) significantly decreased (p < 0.05). Reactive oxygen species (ROS) significantly increased (p < 0.001), but no significant changes were observed in nitric oxide (NO) or myeloperoxidase (MPO) levels. Similarly, inflammatory markers such as C-reactive protein (CRP), MPO, and antioxidant enzymes (glutathione peroxidase [GPx] and catalase [CAT], showed no significant alterations. Among the inflammatory cytokines assessed, interleukin (IL)-1β levels showed a slight increase without reaching significance, and the levels of other cytokines such as IL-6, IL-10, tumor necrosis factor-alpha (TNF-α), and interferon-gamma (IFN-γ) showed no marked alterations. In addition, post-exposure skin assessment revealed no adverse effects. Our findings demonstrate that UVR exposure can enhance vitamin D synthesis in healthy adults without significant inflammatory responses or adverse effects, providing a basis for optimizing UV-based interventions to improve vitamin D status through risk management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.