ArticleCommunications biology2025
Direct excitatory loop and theta resonance in the anterior cingulate-mediodorsal thalamic circuit.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Interactions between the prefrontal cortex and the thalamus are critical for cognitive processing, including working memory and attention. Specifically, theta oscillations in the anterior cingulate cortex (ACC) and mediodorsal thalamic nucleus (MDT) during cognitive tasks are associated with persistent neural activity during working memory; however, the cellular mechanisms underlying the theta oscillations remain unclear. Using targeted patch-clamp recordings combined with neuronal projection identification in rats, we demonstrate that there is a subcircuit of monosynaptically interconnected ACC and MDT neurons to form a positive feedback loop. Synaptic transmission from the ACC to the MDT exhibits short-term facilitation, particularly within the theta frequency range. Moreover, MDT-projecting ACC neurons display a membrane potential resonance at theta frequencies. The results show that the ACC-MDT pathway exhibits synaptic facilitation and membrane resonance preferentially at theta frequencies, indicating that the circuit is tuned to theta dynamics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.