Evidence map›Paper›PMID 40594985›Full record

ArticleCommunications biology2025

Site- and cell-type-specific miRNA and mRNA genes and networks across the cortex, striatum, and hypothalamus.

Amanda M Zacharias, Ciara D O'Connor, Danai G Topouza, Zhi Yi Fang, Helia Ghazinejad, Hanlin Chen, Qingling Duan, Nader Ghasemlou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amanda M ZachariasDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.ORCID http://orcid.org/0000-0002-5598-0232
Ciara D O'ConnorDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.ORCID http://orcid.org/0000-0003-3211-2237
Danai G TopouzaDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.ORCID http://orcid.org/0000-0002-6897-9281
Zhi Yi FangDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.ORCID http://orcid.org/0009-0000-1945-9258
Helia GhazinejadDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.ORCID http://orcid.org/0009-0007-4936-7574
Hanlin ChenDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.ORCID http://orcid.org/0000-0001-6205-3122
Qingling Duan *Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada. qingling.duan@queensu.ca.ORCID http://orcid.org/0000-0003-4467-7024
Nader Ghasemlou *Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada. nader.ghasemlou@queensu.ca.ORCID http://orcid.org/0000-0002-1696-7342

Funding

Gouvernement du Canada | Instituts de Recherche en Santé du Canada | CIHR Skin Research Training Centre (Skin Research Training Centre) PJT-190170Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (Conseil de Recherches en Sciences Naturelles et en Génie du Canada) RGPIN-05604
6 · The paper itself

Abstract

Biological rhythms control gene expression, but effects on central nervous system (CNS) cells and structures remain poorly defined. While circadian (24-hour) rhythms are most studied, many genes have periods of greater and less than 24-hours; these fluctuations can be both site- and cell-specific. Identifying patterns of gene rhythmicity across the CNS is necessary for both the study of chronobiology and to make sense of data obtained in the laboratory. We now identify cycling mRNAs, miRNAs, gene networks and mRNA-miRNA co-expression pairs in the cortex, hypothalamus, and corpus striatum of male C57BL/6J mice using high-dimensional datasets. A searchable catalogue ( https://www.ghasemloulab.ca/chronoCNS ) helps refine the analysis of cellular and molecular rhythmicity across the CNS (using the liver as a control). Immunofluorescence confirms the rhythmicity of key targets across cells in these structures, with strong cycling signatures in resting oligodendrocytes. Our study sheds light on the contribution of diurnal, ultradian, and infradian rhythms and mRNA-miRNA interactions to CNS function.

Indexed as

Cerebral CortexCorpus StriatumGene Regulatory NetworksHypothalamusMicroRNAsRNA, MessengerAnimalsCircadian RhythmGene Expression RegulationMaleMiceMice, Inbred C57BLMicroRNAsRNA, Messenger

Identifiers

PMID40594985
PMCPMC12218356

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.