ArticleScientific reports2025
One-year longitudinal association between changes in aortic regional morphology and muscle mass in cancer.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Aortic response to cancer therapy: a narrative review of the radiotherapy paradox and clinical implications.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Cancer confers the risk for cardiovascular diseases. This longitudinal study aimed to explore the relationship between changes in aortic morphology and muscle mass in cancer. One hundred patients with cancer who underwent thoracoabdominal enhanced computed tomography (CT) at baseline and 1-year follow-up were retrospectively included. Aortic diameter and tortuosity were assessed using CT. Skeletal muscle mass was also evaluated. Pearson correlation analysis and multivariate-adjusted regression models were used to explore the relationship between changes in aortic morphology and muscle mass. Thirty-six patients were male. The average patient age was 57.3 ± 11.3 years. Breast cancer was the most common malignancy. A significant increase in aortic diameter and tortuosity and a decrease in muscle mass were observed. Aortic morphological changes were correlated with changes in muscle mass, diastolic pressure, and high-density lipoprotein cholesterol and C-reactive protein levels. In the fully adjusted multivariable regression analysis, a one-unit increase in muscle mass change was associated with a decrease of 0.503, 0.382, 0.241, 0.174, and 0.163 mm in the diameter of the L1-L5 aortic segments, respectively; a 0.020 decrease in aortic tortuosity; a 0.017 decrease in descending thoracic tortuosity; and a 0.016 decrease in abdominal aortic tortuosity. Increased muscle mass helps maintain aortic morphology in cancer, suggesting that muscle loss is a key factor in increased cardiovascular risk. Muscle might be an important therapeutic target to improve cancer patients' prognosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.