Evidence map›Paper›PMID 40594876›Full record

ArticleScientific reports2025

Sedentary behavior accelerates biological aging mediated by body mass index in adults.

Jinhang Che, Jie Huai, Lihong Luo, Yunxiang Tang, Tao Zeng

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Jinhang CheDepartment of Electrocardiographic Diagnosis, The Fourth People's Hospital of Chengdu, Chengdu, China.
Jie HuaiDepartment of Electrocardiographic Diagnosis, The Fourth People's Hospital of Chengdu, Chengdu, China.
Lihong LuoDepartment of Electrocardiographic Diagnosis, The Fourth People's Hospital of Chengdu, Chengdu, China.
Yunxiang TangDepartment of Electrocardiographic Diagnosis, The Fourth People's Hospital of Chengdu, Chengdu, China.
Tao ZengDepartment of Ultrasonography, The Fourth People's Hospital of Chengdu, No. 8, Huli West Lane, Yingmen, Jinniu District, Chengdu, 610000, China. zengtao110714@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sedentary behavior is widely recognized as a detriment to health. Limited conclusions have been drawn about the relationship between sitting time and biomarkers-measured aging. 12,504 eligible adults were included from the National Health and Nutrition Examination Survey (NHANES) 2007 to 2016. Weighted logistic regression, subgroup analysis, and restricted cubic spline regression were conducted to investigate the association and dose-response relationship between sitting time and phenotypic age acceleration (PhenoAgeAccel). The mediating effect of body mass index (BMI) on this correlation was revealed by mediation analysis. After adjusting for multiple covariates, longer sitting time (4-6 h: OR 1.30, 95%CI 1.06-1.58, p = 0.013; 6-8 h: OR 1.25, 95%CI 1.01-1.55, p = 0.038; ≥8 h: OR 1.58, 95%CI 1.33-1.88, p < 0.001) significantly had higher risk of aging comparing to the reference (< 4 h). The dose-response relationship exhibited an approximately linear dependence. Additionally, BMI partially mediated the association between sitting time and PhenoAgeAccel by a 21.0% proportion. Our study revealed a strong, significant, independent, linear relationship between sitting time and phenotypic age. BMI served as a mediator of the correlation between sitting time and PhenoAgeAccel.

Indexed as

AgingBody Mass IndexSedentary BehaviorAdultAgedFemaleHumansMaleMiddle AgedNutrition SurveysBody mass indexPhenotypic ageSedentary behaviorSitting time

Identifiers

PMID40594876
PMCPMC12219758

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