Evidence map›Paper›PMID 40594846›Full record

ArticleScientific reports2025

Prolonged administration of ritodrine hydrochloride in women with premature labor or threatened premature delivery based on empirical data in Japan.

Kohei Ogawa, Daisuke Shinjo, Tomo Suzuki, Hiromitsu Azuma, Seiji Wada, Kiyohide Fushimi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kohei Ogawa *Center for Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo , 157-8535, Japan.
Daisuke Shinjo *Department of Health Policy and Informatics, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan. dshinjo.hci@tmd.ac.jp.
Tomo SuzukiCenter for Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo , 157-8535, Japan.
Hiromitsu AzumaCenter for Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo , 157-8535, Japan.
Seiji WadaCenter for Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo , 157-8535, Japan.
Kiyohide FushimiDepartment of Health Policy and Informatics, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.

Funding

Fostering Joint International Research (A) 21KK0275Grant-in-Aid for Policy Planning and Evaluation Research from the Japan's Ministry of Health, Labor and Welfare 22AA2003Grant-in-Aid for Scientific Research (B) 20H03921Grant-in-Aid for Scientific Research (C) from the Japan Society for the Promotion of Science 20K18181Grant-in-Aid for Scientific Research (C) from the Japan Society for the Promotion of Science 21K10299Research Development Grant for Child Health and Development from the National Center for Child Health and Development 2024B-19
6 · The paper itself

Abstract

In Japan, maintenance tocolysis has been conventionally administered. The current study aimed to identify the annual trends in the prolonged administration of ritodrine hydrochloride and its differences in terms of region and type of facility. This study used data from the Japanese Diagnosis Procedure Combination inpatient database, and the survey included women with premature labor or threatened premature delivery based on the International Statistical Classification of Diseases and Related Health Problems, 10th Revision, codes. The primary outcome was prolonged administration of ritodrine hydrochloride, defined as treatment for ≥ 4 days. The primary exposures were type of institution, regions where the institutions are located, and year at admission. The effect of each exposure on prolonged administration was assessed via multivariate-modified Poisson regression analysis. Of 280,734 female participants, 180,674 received prolonged administration of ritodrine hydrochloride. Women in primary hospitals had a significantly more prolonged duration of administration than those in tertiary hospitals. Prolonged administration was significantly more common in Hokkaido, Chubu, Kansai, and Shikoku than in Tokyo. Conversely, Kyushu had a significantly lower adusted risk ratio than Tokyo. The prolonged administration of ritodrine hydrochloride has been gradually decreasing annually. However, the rate differed in terms of regions and type of facility.

Indexed as

Obstetric Labor, PrematurePremature BirthRitodrineTocolytic AgentsAdultDatabases, FactualFemaleHumansJapanPregnancyRitodrineTocolytic AgentsDiagnosis procedure combinationMagnesium sulfatePremature laborRitodrine hydrochlorideThreatened premature delivery

Identifiers

PMID40594846
PMCPMC12218401

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.