Evidence map›Paper›PMID 40594842›Full record

ArticleCommunications biology2025

Higher dopamine D1 receptor expression in prefrontal parvalbumin neurons underlies higher distractibility in marmosets versus macaques.

Mary Kate P Joyce, Tsvetoslav G Ivanov, Fenna M Krienen, Jude F Mitchell, Shaojie Ma, Wataru Inoue, Anirvan S Nandy, Dibyadeep Datta, Alvaro Duque, Jon I Arellano and 8 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Mary Kate P Joyce *Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA.
Tsvetoslav G Ivanov *School of Engineering Mathematics & Technology, University of Bristol, Bristol, UK.ORCID http://orcid.org/0009-0007-0321-2286
Fenna M KrienenPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0002-1400-6820
Jude F MitchellDepartment of Brain and Cognitive Sciences, University of Rochester, Rochester, NY, USA.
Shaojie MaDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-8782-3047
Wataru InoueRobarts Research Institute, Western University, London, ON, Canada.
Anirvan S NandyDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-4225-5349
Dibyadeep DattaDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Alvaro DuqueDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-5086-5438
Jon I ArellanoDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT, USA.
Rahul GuptaSchool of Engineering Mathematics & Technology, University of Bristol, Bristol, UK.
Guillermo Gonzalez-BurgosDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-1650-8111
David A LewisDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-3225-6778
Nenad SestanDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-0966-9619
Steven A McCarrollDepartment of Genetics, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6954-8184
Julio Martinez-TrujilloRobarts Research Institute, Western University, London, ON, Canada.ORCID http://orcid.org/0000-0003-3338-578X
Seán Froudist-WalshSchool of Engineering Mathematics & Technology, University of Bristol, Bristol, UK. sean.froudist-walsh@bristol.ac.uk.ORCID http://orcid.org/0000-0003-4070-067X
Amy F T ArnstenDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT, USA. amy.arnsten@yale.edu.ORCID http://orcid.org/0000-0002-3420-1308

Funding

National Science Foundation (NSF) NSF 2015276
6 · The paper itself

Abstract

Marmosets and macaques are common nonhuman primate models of cognition, yet marmosets appear more distractible and perform worse in cognitive tasks. The dorsolateral prefrontal cortex (dlPFC) is pivotal for sustained attention, and research in macaques suggests that dopaminergic modulation and inhibitory parvalbumin (PV) neurons could influence distractor resistance. Here we compare the two species using a visual fixation task with distractors, perform molecular and anatomical analyses in dlPFC, and link functional microcircuitry with cognitive performance using computational modeling. We show that marmosets are more distractible than macaques, and that marmoset dlPFC PV neurons contain higher levels of dopamine D1 receptor (D1R) transcripts and protein, similar to levels in mice. Our modeling indicates that higher D1R expression in marmoset dlPFC PV neurons may increase distractibility by making dlPFC microcircuits more vulnerable to disruptions of their task-related persistent activity, especially when dopamine is released in dlPFC in response to unexpected salient stimuli.

Indexed as

AttentionCallithrixMacacaNeuronsParvalbuminsPrefrontal CortexReceptors, Dopamine D1AnimalsCognitionFemaleMacaca mulattaMaleParvalbuminsReceptors, Dopamine D1

Identifiers

PMID40594842
PMCPMC12214923

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.