ArticleScientific reports2025
Comparative genomic analysis of bacteriocin genes in Lactobacillus crispatus strains.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed.
- From predicted bacteriocins to ecological function.Current research in microbial sciences · 2026Review
- Article
- Postbiotics and paraprobiotics in food biochemistry mechanisms stability and nutritional applications.NPJ science of food · 2026Review
- Precision Microbial Therapeutics for Infertility: Next-Generation Probiotics, Engineered Biologics and Translational Pathways.Microbial biotechnology · 2026Review
- What is the impact of the virome and mycobiome on female reproductive tract health? A systematic scoping review.Frontiers in immunology · 2026Article
- Probiogenomics as a Computational Biotechnology Framework: Safety-Gated Genome Analytics for Candidate Probiotic Prioritization and Validation.Computational and structural biotechnology journal · 2026Review
- Cell-Free but potent: Antimicrobial potential of Lactobacillus supernatants against multidrug-resistant pathogens.PloS one · 2026Article
- Article
- CoDing Sequence Typer (CDST): a fast, simple, decentralized and interoperable solution for bacterial genomic typing and clustering.Microbial genomics · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Lactobacillus crispatus, a key member of the vaginal microbiota, exhibits strain-specific diversity with important implications for host-microbe interactions and probiotic potential. This study investigates the genomic relationships and bacteriocin diversity across 95 L. crispatus strains to elucidate the mechanisms underlying strain-specific adaptation and microbial competitiveness. Using publicly available data from NCBI, we applied BAGEL4 and core genome multilocus sequence typing (cgMLST) approaches to identify and characterize bacteriocin genes, revealing a high level of conservation of major bacteriocins among strains. Analysis of nucleotide polymorphisms within bacteriocin-encoding sequences showed that these genes are generally conserved, likely due to strong purifying selection. These findings suggest that bacteriocins in L. crispatus are functionally conserved, underscoring their potential role in maintaining vaginal health through microbial competition and pathogen exclusion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.