ArticleScientific reports2025
Identification of ferroptosis related genes and subtypes in colorectal cancer.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Interaction Between Iron and Selenium Affects Ferroptosis in Colorectal Cancer.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related deaths worldwide. Increasing evidence has shown that ferroptosis plays a significant regulatory role in the occurrence and progression of cancer. However, new biomarkers associated with ferroptosis and new ferroptosis-related subtypes in CRC remain to be identified. We collected a colon adenocarcinoma (COAD) dataset from the cancer genome atlas (TCGA) database in UCSC Xena. Ferroptosis-related genes (FRGs) were extracted from the dataset, and we conducted gene expression profiling interactive analysis (GEPIA), cBioPortal analysis, and immune cell infiltration analysis. Additionally, we used the "ConsensusClusterPlus" R package to identify ferroptosis-related subtypes of CRC. Based on these subtypes, we analyzed their prognostic features, gene co-expression networks, and the ferroptosis landscape. We identified 21 FRGs in COAD. The genes RBMS1, NOX4, FABP4, CYB5R1, CPEB1, and ATM were significantly and positively correlated with immune cell infiltration and poor prognosis. Furthermore, we identified two COAD subtypes related to prognosis and ferroptosis (ferroptosis subtype 1 [FS1] and ferroptosis subtype 2 [FS2]). These subtypes were associated with tumor mutation burden (TMB), mutation status, immunogenic cell death (ICD), and immune checkpoint (ICP) regulatory genes. Finally, we established a ferroptosis landscape of COAD. We identified key ferroptosis-related genes and defined two distinct ferroptosis-associated subtypes in CRC that differ significantly in prognosis and immune infiltration. These findings provide new insights into the interaction between ferroptosis and the tumor immune microenvironment, offering potential biomarkers and therapeutic targets for improved diagnosis and personalized treatment of colorectal cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.