ArticleScientific reports2025
Synergistic antimicrobial and probiotic activity of lactic acid bacteria isolated from Tarkhineh against Candida albicans.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Lactiplantibacillus plantarum and Pediococcus acidilactici strains isolated from cattle gut show probiotic potential.BMC microbiology · 2026Article
- Functional, Modeling and Antimicrobial Characterization of Lactobacillus helveticus BGRA43 Isolated from Traditional Iranian Cheese.Probiotics and antimicrobial proteins · 2026Article
- Bactericidal and cell membrane disruption potential of protein extract from buttermilk-derived probioticFrontiers in microbiology · 2026Article
- Engineered Lactiplantibacillus plantarum and Levilactobacillus brevis utilizing ribonucleoprotein-mediated editing for inactivation of hemolysin gene.World journal of microbiology & biotechnology · 2025Article
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Authors and funding
6 authors.
Funding
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Abstract
The aim of the study was to isolate and characterize lactic acid bacteria (LAB) from traditional dairy products (tarkhineh) in Kermanshah in western Iran, with a view to their probiotic potential and antimicrobial activity (Candida albicans). A total of 60 tarkhineh samples were randomly screened to isolate the probiotic bacterial strains. Biochemical and physiological analysis confirmed that the isolates were Gram-positive, catalase-negative, and had a round or rod-shaped morphology, in accordance with the LAB classification. Out of 20 isolated strains, five (Ta12, Ta19, Ta37, Ta51, and Ta58) showed a high survival rate (> 94%) under the initial acidity and bile salt screening conditions, which led to their selection for further study. The rescreening confirmed that these strains can survive (> 54%) in enzymatic conditions of the gastrointestinal tract, including the stomach and intestinal tracts. All five strains showed significant antimicrobial activity against 12 common human pathogens, predominantly Gram-positive species, exhibiting inhibition zones ranging from 13.33 to 25.33 mm. Immunological tests revealed negative hemolysis (γ-hemolysis), which indicates that all five strains are safe. However, strains of Ta19 and Ta51 demonstrated higher susceptibility to nine common antibiotics (cefixime, azithromycin, amoxicillin, doxycycline, sulfamethoxazole, ciprofloxacin, cephalexin, amoxicillin-clavulanic acid, and vancomycin), as evidenced by susceptibility spectrum ranging from 12.00 to 39.67 mm. In addition, these two strains showed superior hydrophobicity (> 57%), satisfactory cell adhesion (> 41%), increased cholesterol uptake (> 37%), enhanced biofilm formation (> 26%), and improved properties of auto-aggregation (> 43%) and co-aggregation (> 36%). Antifungal tests showed that Ta19 at 10
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