ArticleScientific reports2025
Efficacy and safety of a novel multivalent mRNA vaccine against SARS-CoV-2 in experimental animals.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Efficacy and Safety of Messenger RNA Vaccines.Health science reports · 2026Article
- The global threat of vaccine-preventable neurological diseases.Nature reviews. Neurology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
The mRNA vaccine is an innovative new platform that can be developed rapidly, offering a robust tool to managing infectious diseases like COVID-19. However, non-clinical evaluations are essential for safety use. In this study, the efficacy, general toxicity, and safety pharmacology of a novel multivalent mRNA-encapsulated lipid nanoparticle (LNP) vaccine (RGV-DO-003) were evaluated using a focus reduction neutralization test (FRNT), virus challenge test, single- and repeated-dose studies, immunogenicity tests, and neurobehavioral, body temperature, respiratory, and cardiovascular system assessments in experimental animals. The administration route was intramuscular, and the vaccine doses were 5 and 50 μg/head for each efficacy test and toxicity study. Neutralizing antibodies were observed in the vaccinated group through FRNT and virus challenge tests. Macroscopic observations revealed a tendency for the lung lesion area to decrease in the vaccinated group. In the general toxicity study, mild symptoms were observed at the injection site in the vaccine administration group. Immunogenicity analysis revealed an increase in the binding antibody titer in the vaccine-administered group. Safety pharmacology study revealed no significant toxicological changes associated with LNP or vaccine administration. Overall, the RGV-DO-003 mRNA vaccine is effective and safe under experimental conditions, suggesting it is a potential candidate for clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.