ArticleScientific reports2025
Association of urine parabens with liver function in US adolescents based on NHANES 2007-2016.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paraben esters are commonly used as preservatives in cosmetics, personal hygiene products, food and drugs. However, there is a lack of evidence regarding the impact of exposure to Paraben esters on adolescent liver function. We analyzed data from the 2007-2016 National Health and Nutrition Examination Survey (NHANES). Finally, a random sample of 1845 adolescents aged 12 to 19 was selected for the study. The effect of urinary parabens on liver function indexes was analyzed using weighted linear regression to ensure accurate representation of the population. Then, we applied the weighted quantile sum (WQS) analysis and the Bayesian kernel machine regression (BKMR) to examine the associations between parabens and liver function indicators. Based on the results from three different models, four parabens and their total were negatively associated with Albumin (ALB) and Alkaline Phosphatase (ALP), and positively associated with Total Bilirubin (TBIL). Moreover, among the parabens, butyl paraben and propyl paraben had the highest weights. Overall, our results indicate that parabens are significantly but weakly associated with changes in liver function in US adolescents. Further research is needed to explore these relationships.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.