Evidence map›Paper›PMID 40594672›Full record

ArticleScientific reports2025

In-silico analysis of potential phytochemicals targeting mitogen activating protein kinase-14 (MAPK14) gene in colorectal cancer.

Meerab Khalid, Rana Muhammad Mateen, Mohsin Javed, Muhammad Ali, Mohammed Arif Nadeem Saqab, Rukhsana Parveen, Ahmed Asimov, Safura Bibi, Ali Bahadur, Shahid Iqbal and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Meerab KhalidDepartment of Life Sciences, School of Science, University of Management and Technology (UMT), Lahore, 54770, Pakistan.
Rana Muhammad MateenDepartment of Life Sciences, School of Science, University of Management and Technology (UMT), Lahore, 54770, Pakistan.
Mohsin JavedDepartment of Chemistry, School of Science, University of Management and Technology, Lahore, 54770, Pakistan.
Muhammad AliDepartment of Life Sciences, School of Science, University of Management and Technology (UMT), Lahore, 54770, Pakistan.
Mohammed Arif Nadeem SaqabDepartment of Chemistry, School of Science, University of Management and Technology, Lahore, 54770, Pakistan.
Rukhsana ParveenCentre for Applied Molecular Biology, University of the Punjab, Lahore, Pakistan.
Ahmed AsimovComposite Materials Scientific Research Center of Azerbaijan, State University of Economics, 194 Murtuza Mukhtarov, Baku, 1065, Azerbaijan.
Safura BibiDepartment of Botany, University of Agriculture, Faisalabad, 38040, Pakistan.
Ali BahadurNanomaterials Research Center, Department of Chemistry, College of Science, Mathematics, and Technology, Wenzhou-Kean University, Wenzhou, 325060, Zhejiang Province, China. abahadur@wku.edu.cn.
Shahid IqbalNottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, 315100, China. shahidgcs10@yahoo.com.
Sajid MahmoodLow Dimensional Materials Research Center, Khazar University, Baku, 1096, Azerbaijan.
Salah KnaniCenter for Scientific Research and Entrepreneurship, Northern Border University, Arar, 73213, Saudi Arabia.
Abeer Ahmed AlghamdiDepartment of Physics, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia.
Randa A AlthobitiDepartment of Chemistry, College of Science, University of Bisha, P.O Box 551, Bisha, 61922, Saudi Arabia.
Lamiaa Galal AminDepartment of Physics, College of Science, Northern Border University, Arar, Saudi Arabia.

Funding

Princess Nourah Bint Abdulrahman University PNURSP2025R451
6 · The paper itself

Abstract

A significant percentage of colorectal cancer (CRC) diagnoses are associated with overexpression of the MAPK14 gene MAPK14 gene or p38 MAPK. It is overexpressed in most cases of colorectal cancer (CRC) and is an important factor for tumor development. CRC is among the most common causes of cancer-related deaths globally It is potent to target this gene for therapeutic intervention because it is important for tumor immune evasion, cell proliferation, survival, and resistance to therapy. By developing treatment techniques that target MAPK14 is a promising approach. In this study, we employed in silico methods to evaluate the potential of phytochemicals as inhibitors of MAPK14, which is overexpressed in CRC. We also included Fruquintinib, an FDA-approved anticancer drug, as a reference compound for molecular docking with MAPK14. Compounds meeting acceptable ADMET profiles were further analyzed using molecular docking, DFT, and MD simulations to identify potential MAPK14 inhibitors. Compound 1 (CID: 44586092) was discovered in our investigation to be a potential therapy for CRC associated with MAPK14.

Indexed as

Colorectal NeoplasmsMitogen-Activated Protein Kinase 14PhytochemicalsProtein Kinase InhibitorsComputer SimulationHumansMolecular Docking SimulationMolecular Dynamics SimulationMitogen-Activated Protein Kinase 14PhytochemicalsProtein Kinase InhibitorsCRC (CRC)DFTFruquintinibIn silicoMAPK14MD

Identifiers

PMID40594672
PMCPMC12215672

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.