ArticleScientific reports2025
Increased plasma GPNMB levels in patients with parkinson's disease and cognitive impairment.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- GPNMB modulates neutrophil extracellular trap formation: therapeutic implications for ischemic stroke.Journal of neuroinflammation · 2026Article
- Integrative clinical and genomic analyses reveal a causal role of GPNMB in the bone-brain axis of Parkinson's disease.NPJ Parkinson's disease · 2026Article
- GPNMB, LRRK2, and lysosome exocytosis in Parkinson's.Science advances · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
Glycoprotein nonmetastatic melanoma protein B (GPNMB) is a glycosylated type I transmembrane protein that forms soluble GPNMB upon maturation. This study aimed to explore the relationship between plasma GPNMB levels in patients with Parkinson's disease (PD) and their clinical manifestations, as well as their correlations with specific brain regions identified through imaging analysis. This study included patients with PD and healthy control subjects whose plasma GPNMB levels measured by enzyme-linked immunosorbent assay (ELISA). Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) scale. The imaging analysis employed voxel-based morphometry (VBM) to detect changes in gray matter volume, with the left lentiform nucleus identified as the region of interest (ROI). The results showed that plasma GPNMB levels were significantly correlated with PD-related cognitive impairment. Specifically, elevated plasma GPNMB levels were associated with deficits in scores for MoCA subitems related to delayed memory. The imaging analysis revealed a moderate negative correlation between plasma GPNMB levels and the gray matter volume in the left putamen, suggesting that this area may be a potential site of action for GPNMB in the pathology of PD. This study is the first comprehensive investigation into the interrelationships between plasma GPNMB levels and the clinical symptoms and imaging characteristics of PD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.