ArticleScientific reports2025
Synergistic and antagonistic contributions of main components to the bioactivity profile of Anethum graveolens extract.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed.
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- Chemical profiling by LC-MS/MS and GC-MS and biological activity assessment of different extracts of Portulaca oleracea through in-vitro and in-silico approaches.Scientific reports · 2025Article
- Eco-friendly remediation of Triflumuron-induced stress with Capsella bursa-pastoris extract.Scientific reports · 2025Article
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- The natural and eco-friendly role of Cassia angustifolia in reducing carbaryl toxicity at environmentally relevant concentration.Scientific reports · 2025Article
- In-silico receptor interactions, phytochemical fingerprint and biological activities of Matricaria chamomilla flower extract and the main components.Scientific reports · 2025Article
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3 authors.
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Abstract
In this study, phytochemical characterization of Anethum graveolens extract, in-vitro, in-vivo and in-silico biological activities and synergistic and antagonistic effects of main components were investigated. Advanced analytical techniques such as LC-MS/MS and GC-MS were integrated with in-vitro, in-vivo and in-silico methodologies to provide valuable information on the therapeutic potential of the plant and its synergistic and antagonistic interactions, which are crucial for developing effective plant-based therapeutic agents. LC-MS/MS analysis revealed the presence of protecatechuic aldehyde, sesamol, caffeic acid, vannilin, p-coumaric acid, rutin and quercetin among the standards tested. Among the essential oils, γ-terpinene, limonene, γ-cadinene, dillapiole were detected in major proportions. The radical scavenging activity of A. graveolens extract was investigated by DPPH and superoxide anion scavenging tests. DPPH scavenging activity was observed in the range of 15.9-80.8% and superoxide anion scavenging activity in the range of 11.5-69.9%. The extract exhibited a broad spectrum activity against all tested microorganism species and the antimicrobial activity ranking among microorganisms was gram-positive > gram-negative > fungus. A. graveolens extract exhibited an inhibition zone of 15.2 ± 0.4 against E. coli and the main components tested individually exhibited a lower activity. And also MIC and MBC values obtained with four main components were higher compared to the extract.This indicates that the extract exhibits a stronger antimicrobial activity due to the cumulative and synergistic effects of the active ingredients in the content. The most prominent synergistic effect was found in anti-genotoxic activity. While the most common fragment rate among the chromosomal aberrations induced by NaN
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