Evidence map›Paper›PMID 40594532›Full record

ArticleScientific reports2025

Genomic analysis of Inonotus hispidus provides insights into its medicinal properties and evolutionary dynamics.

Dingbang Ding, Hua Wang, Jiajun Liang, Chao Su, Minjuan Zhang, Feng Jiao, Lijun Bao, Xia Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dingbang DingCollege of Animal Science and Technology, Northwest A&F University, Yangling, 712100, Shaanxi, China.
Hua WangCollege of Animal Science and Technology, Northwest A&F University, Yangling, 712100, Shaanxi, China.
Jiajun LiangCollege of Animal Science and Technology, Northwest A&F University, Yangling, 712100, Shaanxi, China.
Chao SuCollege of Animal Science and Technology, Northwest A&F University, Yangling, 712100, Shaanxi, China.
Minjuan ZhangCollege of Animal Science and Technology, Northwest A&F University, Yangling, 712100, Shaanxi, China.
Feng JiaoCollege of Animal Science and Technology, Northwest A&F University, Yangling, 712100, Shaanxi, China.
Lijun BaoCollege of Animal Science and Technology, Northwest A&F University, Yangling, 712100, Shaanxi, China. baolijun@nwafu.edu.cn.
Xia WangCollege of Animal Science and Technology, Northwest A&F University, Yangling, 712100, Shaanxi, China. xiawang@nwafu.edu.cn.

Funding

Autonomous innovation project of Henan Academy of Agricultural Sciences 2024ZC122the China Agriculture Research System of MOF and MARA CARS-18the Fundamental Research Funds for the Central Universities 2452022006
6 · The paper itself

Abstract

Inonotus hispidus, a fungal species morphologically closely related to the medicinal genus Sanghuang,has garned considerable attention due to its potential health-prompting benefits. This study presents the whole-genome sequence of I. hispidus ZA-14, a monokaryotic strain isolated from wild fruiting bodies growing in Morus alba (hereinafter referred to as MA). The 37.68 Mb genome was assembled from 5771 Mb of raw data, resulting in 51 contigs with a GC content of 48.48%. A total of 8924 protein-coding genes were predicted, with 223 non-coding RNAs identified. The genome analysis revealed a high density of genes associated with secondary metabolite biosynthesis, including those involved in terpenoid, polysaccharide, and flavonoid pathways-key contributors to its medicinal attributes. Comparative genomic analysis with other related fungal species provided insights into the evolutionary dynamics and speciation of I. hispidus. The study also identified a significant enrichment of glycoside hydrolase family genes, suggesting a critical role in nutrient absorption and utilization. These findings enhance our understanding of the genetic basis of I. hispidus's medicinal value and its evolutionary relationships, providing a foundation for future breeding.

Indexed as

BasidiomycotaEvolution, MolecularGenome, FungalGenomicsMorusPhylogenyWhole Genome SequencingComparative genomicsGenomic analysisInonotus hispidusPhylogeneticsSecondary metabolites

Identifiers

PMID40594532
PMCPMC12215927

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.