ArticleScientific reports2025
Effects of piperine on intestinal permeation, pharmacodynamics and pharmacokinetics of insulin loaded chitosan coated solid lipid nanoparticles in rats.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- Development and Validation of a UPLC-MS/MS for Determination of Loureirin D in Rat Plasma and Its Application to Pharmacokinetics.Biomedical chromatography : BMC · 2026Article
- Effect of Piperine Codelivery on the Oral Bioavailability of Cannabidiol: Insights fromJournal of agricultural and food chemistry · 2026Article
- IL-22/IL-22R signaling attenuates mitochondrial damage in PCOS by modulating granulosa cell lipid metabolism through ETS1.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Neuroprotective Effect of Sweet Potato Petiole and Leaf Dry-Powder in a Gerbil Model of Transient Cerebral Ischaemia.Veterinary medicine and science · 2026Article
- Social support and associated factors among diabetic patients in Bahir Dar, Ethiopia: a cross-sectional study.Annals of medicine and surgery (2012) · 2026Article
- Glucose-Responsive PEGDA-GelMA-MPBA Hydrogel Loaded with Exosomes Promotes Diabetic Wound Healing.Journal of diabetes research · 2026Article
- Nonlinear Relationship Between the Triglyceride-Glucose Index and All-Cause and Cardiovascular Mortality in Diabetes Mellitus Patients With Hypertension: A National Cohort Study.International journal of endocrinology · 2026Article
- Optimization of deep eutectic solvent extraction ofFrontiers in pharmacology · 2026Article
- Hybrid GAN-LSTM framework for diabetic foot ulcer image synthesis and automated diagnosis.Frontiers in medicine · 2026Article
- Metabolomics identifies chenodeoxycholic acid as a protective factor in diabetic foot ulcers.Frontiers in endocrinology · 2026Article
- The future of vesicular drug delivery: transferosomes in therapeutic advancement-applications, innovations and challenges.Biomedical engineering online · 2025Review
- Nanoencapsulation of nutraceuticals: enhancing stability and bioavailability in functional foods.Frontiers in nutrition · 2025Review
- Boruta algorithm-guided antibiotic selection in antibiotic-loaded bone cement for diabetic foot ulcers: microbiota and susceptibility analysis.Frontiers in pharmacology · 2025Article
- Methodological panorama of clinical trials for diabetic foot ulcers: a scope review of design, implementation and reporting.Frontiers in endocrinology · 2025Article
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8 authors.
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Abstract
The oral administration of insulin offers significant clinical benefits due to its simplicity. This study evaluated piperine's efficacy in improving insulin's intestinal absorption in Wistar rats. Confocal microscopy demonstrated that prolonged retention of insulin-loaded chitosan-coated solid lipid nanoparticles (Ch-In-SLNs) on intestinal mucosa was due to chitosan's mucoadhesive properties. These studies also revealed Ch-In-SLNs permeation in rat intestinal segments. Piperine enhanced the permeation of insulin-loaded nanoparticles, with more particles transported into deeper intestinal layers. The study assessed Ch-In-SLNs with piperine administered orally to diabetic rats. The formulated SLN's effectiveness was evaluated in vivo in overnight-fasted Wistar rats. Male Wistar rats (n = 5) were divided into 8 groups, with the first as diabetic control, and others receiving various treatments, including blank SLN, oral insulin solution (25 IU/kg), subcutaneous (SC) insulin (5 IU/kg), and insulin nanoformulations (25 IU/kg and 50 IU/kg with and without piperine, respectively). Ch-In-SLN with piperine showed a statistically significant reduction (p < 0.05) in blood glucose levels in streptozotocin-induced (STZ) diabetic rats compared to SLNs without piperine and SC insulin. The Ch-In-SLN with piperine formulation demonstrated a noteworthy correlation between pharmacokinetics (PK) and pharmacodynamics (PD). This approach could replace traditional insulin injections and mitigate associated side effects, simplifying insulin therapy.
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