Evidence map›Paper›PMID 40594446›Full record

ArticleScientific reports2025

Diagnostic value of the diagonal earlobe crease in combination with lipoprotein(a) in coronary heart disease.

Ruoling Guo, Huihui Yang, Jie Dou, Jie Gao, Yuhua Yin, Yu Gu, Lina Liu, Yanchun Yang, Jingtao Guo, Dapeng Zhou and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ruoling GuoGraduate School, Chengde Medical University, Chengde, Hebei, China.
Huihui YangGraduate School, Chengde Medical University, Chengde, Hebei, China.
Jie DouGraduate School, Chengde Medical University, Chengde, Hebei, China.
Jie GaoDepartment of Emergency, Handan City First Hospital, Handan, Hebei, China.
Yuhua YinDepartment of Cardiology, Chengde Central Hospital/Second Clinical College of Chengde Medical University, Chengde, 067000, Hebei, China.
Yu GuDepartment of Cardiology, Chengde Central Hospital/Second Clinical College of Chengde Medical University, Chengde, 067000, Hebei, China.
Lina LiuDepartment of Cardiology, Chengde Central Hospital/Second Clinical College of Chengde Medical University, Chengde, 067000, Hebei, China.
Yanchun YangDepartment of Cardiology, Chengde Central Hospital/Second Clinical College of Chengde Medical University, Chengde, 067000, Hebei, China.
Jingtao GuoDepartment of Cardiology, Chengde Central Hospital/Second Clinical College of Chengde Medical University, Chengde, 067000, Hebei, China.
Dapeng ZhouDepartment of Geriatrics, Chengde Health Care hospital, Chengde, 067000, Hebei, China. zhoudapeng2000@163.com.
Donglei LuoDepartment of Cardiology, Chengde Central Hospital/Second Clinical College of Chengde Medical University, Chengde, 067000, Hebei, China. dongleiluocn@aliyun.com.

Funding

Medical Science Research Project of Hebei Province No. 20200348Project for Cultivating Innovative Ability of Postgraduates at Chengde Medical University CYCXZZ202508S & T Program of Chengde 202109A019
6 · The paper itself

Abstract

To investigate the diagnostic value of diagonal earlobe crease (DELC) combined with lipoprotein(a) [Lp(a)] for coronary heart disease (CHD). A total of 862 chest paint patients suspected of CHD were admitted to Chengde Central Hospital between September 2021 and December 2023. According to CAG results, patients were categorized into the experimental group and the control group. Multifactorial logistic analysis was used to analyze association between DELC and Lp(a) levels with the risk of developing CHD. The diagnostic efficacy of DELC, Lp(a) for CHD was evaluated by receiver operating characteristic (ROC) and area under the curve (AUC). The results showed that DELC and Lp(a) were positively correlated with CHD. Age, sex, hypertension, diabetes mellitus, alopecia, DELC, TG and Lp(a) were independent risk factors for CHD. The CHD diagnostic model was constructed based on these risk factors, with the Hosmer-Lemeshow test (P = 0.683) confirming a good fit. The subjects were categorized into group A, B, C, and D, taking group A as the reference group, and the OR values of groups C and D were significantly increased after multi-factor correction. The area under the DELC and Lp(a) curves calculated by ROC curve was 0.729, indicating a strong diagnostic value for CHD. DELC and Lp(a) were independent risk factors for CHD. The combination of DELC and Lp(a) had good application value in the diagnosis of CHD.

Indexed as

Coronary DiseaseEar, ExternalLipoprotein(a)AdultAgedFemaleHumansMaleMiddle AgedRisk FactorsROC CurveLipoprotein(a)Coronary heart diseaseDiagnosisDiagonal earlobe creaseLipoprotein (a)

Identifiers

PMID40594446
PMCPMC12215279

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.