Evidence map›Paper›PMID 40594416›Full record

ArticleScientific reports2025

Modified stereotactic neurosurgery techniques for rodent surgery enhance survival and reduce surgery time in a severe traumatic brain injury model.

Pongsakorn Wechakarn, Sumeth Klomchitcharoen, Tirapoot Jatupornpoonsub, Nantawachara Jirakittayakorn, Chanon Puttanawarut, Wanlop Likitsuntonwong, Khuanjit Chaimongkolnukul, Yodchanan Wongsawat

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pongsakorn WechakarnBrain-Computer Interface Laboratory, Department of Biomedical Engineering, Faculty of Engineering, Mahidol University, Nakhon Pathom, 73170, Thailand.
Sumeth KlomchitcharoenBrain-Computer Interface Laboratory, Department of Biomedical Engineering, Faculty of Engineering, Mahidol University, Nakhon Pathom, 73170, Thailand.
Tirapoot JatupornpoonsubDepartment of Prosthodontics, Faculty of Dentistry, Mahidol University, Bangkok, 10400, Thailand.
Nantawachara JirakittayakornBrain-Computer Interface Laboratory, Department of Biomedical Engineering, Faculty of Engineering, Mahidol University, Nakhon Pathom, 73170, Thailand.
Chanon PuttanawarutDepartment of Clinical Epidemiology and Biostatistics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 10300, Thailand.
Wanlop LikitsuntonwongNational Laboratory Animal Center, Mahidol University, Nakhon Pathom, 73170, Thailand.
Khuanjit ChaimongkolnukulNational Laboratory Animal Center, Mahidol University, Nakhon Pathom, 73170, Thailand.
Yodchanan WongsawatBrain-Computer Interface Laboratory, Department of Biomedical Engineering, Faculty of Engineering, Mahidol University, Nakhon Pathom, 73170, Thailand. yodchanan.won@mahidol.ac.th.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Controlled cortical impact (CCI) is the most widely used mechanical model of traumatic brain injury (TBI) in rodent brains. This neurosurgical procedure generally involves the use of a stereotaxic system, which requires reaching a specific brain region with the most accurate position possible. In this study, a modified stereotaxic system for TBI induction was developed to evaluate preclinical research in rodents for conducting neural stimulation experiments by using an implanted electrode to assist in rehabilitation after severe TBI. The proposed model aims to reduce animal mortality during surgery and alleviate the negative side effects potentially caused by prolonged anesthesia drug usage. Isoflurane is applied as an anesthetic drug before stereotaxic surgery in rodents, which promotes hypothermia in the animal body. The result showed notable improvement in rodent survival after applying an active warming pad system to prevent hypothermia. Compared with the conventional stereotaxic system, the modified CCI device with a mounted 3D-printed header significantly improved performance in the surgical procedure, decreasing the total operation time by 21.7%, especially in the Bregma‒Lambda measurement. These findings indicate the tangible capability of our modified stereotaxic system, which allows surgeons to perform stereotaxic surgery faster and lowers the risk of intraoperative mortality.

Indexed as

Brain Injuries, TraumaticNeurosurgical ProceduresStereotaxic TechniquesAnimalsDisease Models, AnimalMaleMiceOperative TimeRatsRats, Sprague-DawleyControlled cortical impactNeurostimulationNeurosurgeryStereotaxicTraumatic brain injury

Identifiers

PMID40594416
PMCPMC12214793

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.