ArticleScientific reports2025
Copper only SOD repeat proteins likely act as an extracellular superoxide dismutase in oyster antioxidant defense.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- Fine-tuning alkyl chain length in copper(II) complexes: effects on DNA binding and catalytic cleavage.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- Copper, cuproptosis, and cancer: biology concepts of a novel cell death.Apoptosis : an international journal on programmed cell death · 2026Review
- From hemocuprein to CSRP: the many faces of Cu/Zn superoxide dismutase.Metallomics : integrated biometal science · 2026Review
- Transcriptome Assembly and Comparative Analysis of the Superoxide Dismutase (SOD) Gene Family in ThreeBiology · 2025Article
- Immunopeptidome Landscape DuringInternational journal of molecular sciences · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
Superoxide dismutases (SODs) are key enzymes involved in oxidative stress regulation. In most eukaryotes, they typically require both copper and zinc for catalysis and structural stability. However, copper-only SODs, previously identified in bacteria and fungi, represent a novel enzyme class with unique catalytic mechanisms. This study investigates copper-only SOD-repeat proteins (CSRPs) in two oyster species, Crassostrea gigas and Crassostrea sikamea, marking the first functional evidence of these proteins as extracellular SODs. Three CSRP genes were identified in each species, with expression localized primarily to the mantle. Structural modeling of a representative protein, Cs-CSRP1, revealed conserved copper-binding sites essential for SOD activity. Functional assays using recombinant Cs-CSRP1 confirmed its SOD activity, supporting its role as a novel extracellular antioxidant enzyme. These findings offer new insights into oyster antioxidant defense mechanisms and the evolution of SOD family proteins.
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Registered trials
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